GEO series
Epigenetic reprogramming drives cellular and phenotypic plasticity in liposarcoma
GSE324208
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
42 samples
Submitted 2026/04/01
Platform GPL24676
Summary
Single-cell multiomic profiling were performed to characterize the cellular and regulatory heterogeneity of liposarcoma (LPS), including well-differentiated liposarcoma (WDLPS) and de-differentiated liposarcoma (DDLPS), which exhibit markedly different clinical behaviors. Integrated scRNA and scATAC were used to resolve tumor cell states, gene regulatory programs, and tumor microenvironment composition across LPS subtypes. The results reveal distinct differentiation landscapes, with DDLPS enriched for progenitor-like mesenchymal cells, sclerotic WDLPS displaying broader lineage plasticity, and adipocytic WDLPS dominated by terminally differentiated adipocytes. Analysis of the tumor microenvironment further demonstrates differences in immune composition, with DDLPS enriched for immunosuppressive macrophages. Sclerotic WDLPS exhibits intermediate cellular and molecular features between the two subtypes. Together, these datasets provide a comprehensive resource describing the transcriptional, epigenomic, and microenvironmental diversity of liposarcoma.
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE324208_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 42 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1367140. Searching any of these in the dataset finder brings you back here.
Study design
40 conditions, each sampled once — no replicated groups
Read from the first 40 of 42 sample titles: 40 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM9571142 scMultiomic RNA-Seq of LPS,1-DD
- GSM9571143 scMultiomic RNA-Seq of LPS,1-WD
- GSM9571144 scMultiomic RNA-Seq of LPS,2-WD-A
- GSM9571145 scMultiomic RNA-Seq of LPS,2-WD-B
- GSM9571146 scMultiomic RNA-Seq of LPS, 3-DD-A
- GSM9571147 scMultiomic RNA-Seq of LPS,3-DD-B
- GSM9571148 scMultiomic RNA-Seq of LPS,4-DD-A
- GSM9571149 scMultiomic RNA-Seq of LPS, 4-DD-B
- GSM9571150 scMultiomic RNA-Seq of LPS, 4-WD
- GSM9571151 scMultiomic RNA-Seq of LPS, 5-WD-A
- GSM9571152 scMultiomic RNA-Seq of LPS, 5-WD-B
- GSM9571153 scMultiomic RNA-Seq of LPS, 6-WD-A
- GSM9571154 scMultiomic RNA-Seq of LPS, 6-WD-B
- GSM9571155 scMultiomic RNA-Seq of LPS, 7-WD-A
- GSM9571156 scMultiomic RNA-Seq of LPS, 7-WD-B
- GSM9571157 scMultiomic RNA-Seq of LPS, 8-DD-8
- GSM9571158 scMultiomic RNA-Seq of LPS, 9-WD-A
- GSM9571159 scMultiomic RNA-Seq of LPS, 9-WD-B
- GSM9571160 scMultiomic RNA-Seq of LPS, 10-DD
- GSM9571161 scMultiomic RNA-Seq of LPS, 11-WD
- GSM9571162 scMultiomic RNA-Seq of LPS, 12-WD
- GSM9571163 scMultiomic ATAC-Seq of LPS,1-DD
- GSM9571164 scMultiomic ATAC-Seq of LPS,1-WD
- GSM9571165 scMultiomic ATAC-Seq of LPS,2-WD-A
- GSM9571166 scMultiomic ATAC-Seq of LPS,2-WD-B
- GSM9571167 scMultiomic ATAC-Seq of LPS, 3-DD-A
- GSM9571168 scMultiomic ATAC-Seq of LPS,3-DD-B
- GSM9571169 scMultiomic ATAC-Seq of LPS, 4-DD-A
- GSM9571170 scMultiomic ATAC-Seq of LPS, 4-DD-B
- GSM9571171 scMultiomic ATAC-Seq of LPS, 4-WD
- GSM9571172 scMultiomic ATAC-Seq of LPS, 5-WD-A
- GSM9571173 scMultiomic ATAC-Seq of LPS, 5-WD-B
- GSM9571174 scMultiomic ATAC-Seq of LPS, 6-WD-A
- GSM9571175 scMultiomic ATAC-Seq of LPS, 6-WD-B
- GSM9571176 scMultiomic ATAC-Seq of LPS, 7-WD-A
- GSM9571177 scMultiomic ATAC-Seq of LPS, 7-WD-B
- GSM9571178 scMultiomic ATAC-Seq of LPS, 8-DD-8
- GSM9571179 scMultiomic ATAC-Seq of LPS, 9-WD-A
- GSM9571180 scMultiomic ATAC-Seq of LPS, 9-WD-B
- GSM9571181 scMultiomic ATAC-Seq of LPS, 10-DD
+ 2 more — browse all 42 samples with per-sample file links →
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