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Cell composition and gene-expression dynamics of skeletal muscle regeneration after contraction-induced injury

GSE306977 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing; Other 70 samples Submitted 2025/12/02 Platform GPL24676Platform GPL24247
Summary
Small-molecule activators targeting the allosteric drug and metabolite (ADaM) site of AMPK enhance insulin-independent glucose uptake in skeletal muscle and promote blood glucose lowering in preclinical models of hyperglycemia. The regulatory AMPKγ subunit plays a central role in energy sensing, and the skeletal muscle-selective γ3 isoform is essential for AMP/ZMP-induced glucose uptake, but not for ADaM site activators. We hypothesized that the predominant γ1 isoform is required for ADaM site activator-stimulated glucose uptake in skeletal muscle.
Published in
Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle
Biswas D, Espino-Gonzalez E, Ahwazi D et al. · Molecular metabolism 2026 · PMID 41325841 · doi:10.1016/j.molmet.2025.102294
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Direct links to NCBI, no account and no request form: the whole study as GSE306977_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 70 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1314071 and SRA study SRP616680. Searching any of these in the dataset finder brings you back here.

Study design
40 conditions, each sampled once — no replicated groups

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