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Engineered thoracic spinal cord organoids for transplantation after spinal cord injury

GSE305911 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing; Other 26 samples Submitted 2025/08/21 Platform GPL30172Platform GPL29480Platform GPL30173
Summary
Human iPSC-derived thoracic spinal cord organoids were transplanted into spinal cord injury mice, and spinal cord tissue was collected after 7 weeks. The transplantation resulted in functional recovery and neural circuit remodeling in the injured mice.
Published in
Engineered thoracic spinal cord organoids for transplantation after spinal cord injury
Zhu Y, Huang R, Yu L et al. · Nature biomedical engineering 2025 · PMID 41136603 · doi:10.1038/s41551-025-01549-8
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Direct links to NCBI, no account and no request form: the whole study as GSE305911_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 26 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1307158 and SRA study SRP609491. Searching any of these in the dataset finder brings you back here.

Study design
7 conditions, mostly in triplicate
enTsOrg_8w ×4 sOrg_8w ×4 iPSC ×3 enTsOrg_2w ×3 enTsOrg_3w ×3 sOrg_2w ×3 sOrg_3w ×3 spinal cord with enTsOrg_7wpi ×1 +2 more

Supports a between-group comparison across 23 samples.

7 replicated groups read from 26 sample titles; they account for 23 of them. Check it against the sample list below before relying on it.

Samples in this study
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