GEO series

Selective targeting of HIV infected clones by cognate peptide stimulation and antiproliferative drugs

GSE305896 Homo sapiens Other; Expression profiling by high throughput sequencing 10 samples Submitted 2025/08/25 Platform GPL24676

Summary

Clonal expansion of HIV infected CD4+ T cells is a barrier to HIV eradication. We previously described a marked reduction in the frequency of the most clonally expanded infected CD4+ T cells in an individual with elite control (ES24) after initiating chemoradiation for metastatic lung cancer with a regimen that included paclitaxel and carboplatin. We tested the hypothesis that this phenomenon was due to a higher susceptibility to the chemotherapeutic drugs of CD4+ T cell clones that were sustained by active proliferation. We studied a CD4+ T cell clone with replication-competent provirus integrated into the ZNF721/ABCA11P genes, termed ZNF721i. We stimulated the clone with its cognate peptide and then exposed the cells to paclitaxel and/or carboplatin or the antiproliferative drug, mycophenolate mofetil. While treatment of cells with the cognate peptide alone led to a marked expansion of the ZNF721i clone, treatment with the cognate peptide followed by culture with either paclitaxel or mycophenolate mofetil abrogated this process. The drugs did not affect the proliferation of other CD4+ T cell clones that were not specific for the cognate peptide. This strategy of antigen-specific stimulation followed by treatment with an antiproliferative agent may lead to the selective elimination of clonally expanded HIV-infected cells.

Published in

Selective targeting of HIV-infected clones by cognate peptide stimulation and antiproliferative drugs

Dragoni F, Sop J, Gurumurthy I et al. · The Journal of clinical investigation 2025 · PMID 41118390 · doi:10.1172/JCI197266

This dataset

Open GSE305896 in finder → Find more human datasets →

Download

Direct links to NCBI, no account and no request form: the whole study as GSE305896_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 10 samples. Raw sequencing reads are also available from ENA.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗ Raw reads on ENA ↗

Also filed as BioProject PRJNA1308140. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41118390) ↗

Study design

10 conditions, each sampled once — no replicated groups

Read from 10 sample titles: 10 distinct titles with little repetition. Check it against the sample list below before relying on it.

Similar datasets

Search all human datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.