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Treatment of cholangiocarcinoma using humanized monoclonal antibodies targeting Claudin-1

GSE262166 Homo sapiens Other; Expression profiling by high throughput sequencing 77 samples Submitted 2026/06/08 Platform GPL11154Platform GPL33484Platform GPL24676
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Claudin-1 targeting suppresses tumor growth, invasion, and metastasis in patient-derived cholangiocarcinoma models
Nehme Z, Muller M, Brochon J et al. · Science translational medicine 2026 · PMID 42234772 · doi:10.1126/scitranslmed.adp2595
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE262166_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 77 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1090498 and SRA study SRP496658. Searching any of these in the dataset finder brings you back here.

Study design
7 conditions, mostly with about 4 replicates each
CDX, HuCC-A1, ×5 CDX, EGI-1, ×5 CCA_CTRL_Tum1_plate ×4 CCA_Treated_Tum2_plate ×4 CDX, HuCC-T1, ×4 PDM17_ctl ×3 PDM17_H3L ×3 506 ×1 +11 more

Supports a case/control comparison: 4 samples read as cases, 7 as controls.

7 replicated groups read from the first 40 of 77 sample titles; they account for 28 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 37 more — browse all 77 samples with per-sample file links →

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