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Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR

GSE305889 Homo sapiens; Mus musculus Other; Expression profiling by high throughput sequencing 177 samples Submitted 2025/08/30 Platform GPL28457Platform GPL31277
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR
Wei X, Xu Y, Yang D et al. · Nature biotechnology 2026 · PMID 41714417 · doi:10.1038/s41587-026-03013-7
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE305889_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 177 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1308126 and SRA study SRP506778. Searching any of these in the dataset finder brings you back here.

Study design
32 × human H1, GM12878 and mouse ESC, DNA, batch1, vs 5 × mouse Pvalb neuron, vs 2 × human H1, GM12878 and mouse ESC, RNA, batch2,

Supports a between-group comparison across 39 samples.

3 replicated groups read from the first 40 of 177 sample titles; they account for 39 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 137 more — browse all 177 samples with per-sample file links →

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