Persistent ER stress in macrophages fuels age-related inflammation and vulnerability to infection

Direct links to NCBI, no account and no request form: the whole study as GSE304706_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1302373 and SRA study SRP606958. Searching any of these in the dataset finder brings you back here.

Supports a between-group comparison across 8 samples.

2 replicated groups read from 8 sample titles; they account for 8 of them. Check it against the sample list below before relying on it.

• GSM9155570 Peritoneal macrophages from young mouse, biological replicate 1
• GSM9155571 Peritoneal macrophages from young mouse, biological replicate 2
• GSM9155572 Peritoneal macrophages from young mouse, biological replicate 3
• GSM9155573 Peritoneal macrophages from young mouse, biological replicate 4
• GSM9155574 Peritoneal macrophages from aged mouse, biological replicate 1
• GSM9155575 Peritoneal macrophages from aged mouse, biological replicate 2
• GSM9155576 Peritoneal macrophages from aged mouse, biological replicate 3
• GSM9155577 Peritoneal macrophages from aged mouse, biological replicate 4

• GSE319035 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease [NAFLD_time_course] 77 samples
• GSE293315 MRPGRX2 Antagonist Treatment Prevents Inflammation and Disease in a Mouse Model of Atopic Dermatitis Dataset 2 35 samples
• GSE300288 Single-cell and spatial transcriptomics analysis of tobacco-associated lung adenocarcinoma development, and in response to targeting inflammation alone or in combination with immune checkpoint blockade in precancerous phase [scRNA-seq] 31 samples
• GSE321707 Characterization of TLR signaling in Ticam2-/- macrophages 30 samples
• GSE327176 Single-cell transcriptomic profiling unveils tumor-mediated reprogramming of neutrophils and their unique vulnerability that inhibits metastasis 25 samples
• GSE309993 Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection 25 samples
• GSE337190 CAR-NKT cells induce low cytokine release syndrome by targeting hyperinflammatory macrophages with mitigation from GM-SCF inhibition. 24 samples
• GSE304391 Global identification of ER stress-regulated RNA binding Proteins in clonal pancreatic beta-cells, reveals an important role for DEAD-box helicase 3 X-linked (DDX3X) in the execution of the Unfolded Protein Response and the determination of cell fate. 12 samples

Search all mouse RNA-seq datasets in GEO →