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Functional redundancy between UTY and UTX in regulating the localization of transcription factors involved in pluripotency

GSE301298 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing 88 samples Submitted 2026/04/09 Platform GPL15520Platform GPL16791
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Functional redundancy between UTY and UTX in regulating the localization of transcription factors involved in pluripotency
Akiyama T, Nakahara T, Sato S et al. · Development (Cambridge, England) 2026 · PMID 41906541 · doi:10.1242/dev.205328
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE301298_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 88 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1284756 and SRA study SRP596366. Searching any of these in the dataset finder brings you back here.

Study design
15 conditions, mostly in duplicate
UTX_Flag_hES ×3 UTY_Flag_hES ×3 H3K27me3_hES ×2 H3K27me3_DKO ×2 JMJD3_Flag_Dif ×2 OCT4_hES ×2 OCT4_UTXKO ×2 OCT4_DKO ×2 +15 more

Supports a between-group comparison across 32 samples.

15 replicated groups read from the first 40 of 88 sample titles; they account for 32 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 48 more — browse all 88 samples with per-sample file links →

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