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Comprehensive profiling of N6-methyladnosine (m6A) readouts reveals novel m6A readers that regulate human embryonic stem cell differentiation [GLORI-seq]

GSE290408 Homo sapiens Other; Expression profiling by high throughput sequencing 12 samples Submitted 2026/02/09 Platform GPL24676
Summary
GLORI-Seq is an antibody-independent sequencing, which can detect m6A sites at single-base. The core of GLORI-Seq is to find a catalytic system of glyoxal and nitrite through chemical reaction combination screening, which efficiently deaminate unmethylated adenosine A to form inosine (A-to-I, > 98%). Inosine is read to guanosine (G) in the sequencing process, forming A-to-G conversion. GLORI-Seq enables single base detection of single base m6A by detecting the proportion of “A” in the sequenced read sequence.
Published in
Comprehensive Profiling of N(6)-methyladnosine (m(6)A) Readouts Reveals Novel m(6)A Readers That Regulate Human Embryonic Stem Cell Differentiation
Huang Z, Liu R, Wubulikasimu Z et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 · PMID 41560347 · doi:10.1002/advs.202510075
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Also filed as BioProject PRJNA1227924 and SRA study SRP566193. Searching any of these in the dataset finder brings you back here.

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