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Integrated Single-Cell and Spatial Transcriptomics Uncover Distinct Cellular Subtypes Involved in Neural Invasion in PDAC [scRNA-Seq]

GSE278688 Homo sapiens Expression profiling by high throughput sequencing 29 samples Submitted 2025/05/19 Platform GPL24676
Summary
This study aims to explore the role of nerves in tumor biology, particularly focusing on their function and the impact of the neural microenvironment in cancer invasion. Utilizing multi-omics technologies, we have mapped the spatial transcriptomic landscape of nerve-associated cells in pancreatic ductal adenocarcinoma (PDAC). By analyzing tissue samples with varying degrees of neural invasion, we have uncovered the complex interactions between tumor cells, immune cells, and neurons, providing new insights into the mechanisms underlying nerve-tumor interactions. This research lays the groundwork for future studies in cancer neuroscience and potentially advances the development of novel therapeutic strategies.
Published in
Integrated single-cell and spatial transcriptomics uncover distinct cellular subtypes involved in neural invasion in pancreatic cancer
Chen MM, Gao Q, Ning H et al. · Cancer cell 2025 · PMID 40680743 · doi:10.1016/j.ccell.2025.06.020
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Also filed as BioProject PRJNA1168417. Searching any of these in the dataset finder brings you back here.

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