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Single Cell Transcriptomics of human carotid artery plaques V2

GSE294291 Homo sapiens Expression profiling by high throughput sequencing 14 samples Submitted 2025/11/04 Platform GPL34284
Summary
We profiled the single-cell transcriptome and analyzed the diversity of cell types present in human atherosclerotic tissue specimens (carotid artery, CAR). Therefore we carried out scRNA-seq from 7 different patients.
Published in
Single cell spatial transcriptomics integration deciphers the morphological heterogeneity of atherosclerotic carotid arteries
Pauli J, Garger D, Peymani F et al. · Nature communications 2025 · PMID 41413386 · doi:10.1038/s41467-025-67679-4
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE294291_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 14 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1248935 and SRA study SRP577978. Searching any of these in the dataset finder brings you back here.

Study design
7 conditions, mostly in duplicate
scSeq_CAR11_Seq ×2 scSeq_CAR12_Seq ×2 scSeq_CAR13_Seq ×2 scSeq_CAR14_Seq ×2 scSeq_CAR15_Seq ×2 scSeq_CAR16_Seq ×2 scSeq_CAR17_Seq ×2

Supports a between-group comparison across 14 samples.

7 replicated groups read from 14 sample titles; they account for 14 of them. Check it against the sample list below before relying on it.

Samples in this study
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