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Disruption of the Integrator complex triggers the Integrated Stress Response through formation of double-stranded RNA

GSE267239 Homo sapiens Other; Expression profiling by high throughput sequencing 57 samples Submitted 2025/04/16 Platform GPL24676Platform GPL21697
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Integrator loss leads to dsRNA formation that triggers the integrated stress response
Baluapuri A, Zhao NC, Marina RJ et al. · Cell 2025 · PMID 40233738 · doi:10.1016/j.cell.2025.03.025
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE267239_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 57 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1110594 and SRA study SRP506570. Searching any of these in the dataset finder brings you back here.

Study design
12 conditions, mostly in triplicate
TTseq_INTS1_auxin_minus ×3 TTseq_INTS1_auxin_plus ×3 TTseq_Parental_auxin_minus ×3 TTseq_Parental_auxin_plus ×3 TTseq_INTS8_auxin_minus ×3 TTseq_INTS8_auxin_plus ×3 PROseq_INTS1_auxin_minus ×3 PROseq_INTS1_auxin_plus ×3 +10 more

Supports a between-group comparison across 34 samples.

12 replicated groups read from the first 40 of 57 sample titles; they account for 34 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 17 more — browse all 57 samples with per-sample file links →

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