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Glucocorticoid receptor action in mouse granulosa cells in response to LH surge

GSE249985 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 9 samples Submitted 2026/08/07 Platform GPL19057
Summary
Cortisol is important for folicle survival and oocyte quality. Its ligand, glucocorticoid receptor (GR), is induced in granulosa cells in response to the LH surge, and emerging data suggests that GR plays a role in ovulation. To determine the interrelationship between different steroid receptors in the ovarian context, we generated comprehensive GR cistrome datasets from granulosa cells in response to in vivo LH stimulus.
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Direct links to NCBI, no account and no request form: the whole study as GSE249985_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1051552 and SRA study SRP477558. Searching any of these in the dataset finder brings you back here.

Study design
7 conditions, each sampled once — no replicated groups
PMSG, GR, ×2 hCG, GR, ×2

Read from 9 sample titles: 7 distinct titles with little repetition. Check it against the sample list below before relying on it.

Samples in this study
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