Single-nucleus RNA-Seq and spatial transcriptomics characterization of Alzheimer’s Disease and Down Syndrome

Direct links to NCBI, no account and no request form: the whole study as GSE233208_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 185 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA975472 and SRA study SRP439197. Searching any of these in the dataset finder brings you back here.

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+ 185 more — browse all 185 samples with per-sample file links →

• GSE336954 Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder 126 samples
• GSE274037 A microglia clonal inflammatory disorder in Alzheimer’s Disease 54 samples
• GSE325427 Integrative single-nucleus multiomic, CUT&Tag, and bulk RNA-seq profiling of human and mouse prefrontal cortex reveals gene regulatory mechanisms of cortical development and Meis2 function 34 samples
• GSE242821 Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by single-cell transcriptomics 26 samples
• GSE252238 A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease 23 samples
• GSE278959 Genome-wide DNA replication profiling and full-length total RNA sequencing from the same single cell 546 samples
• GSE282636 Multiplex generation and single cell analysis of structural variants in mammalian genomes 197 samples
• GSE333685 Vascular smooth muscle cell state trajectories mediate molecular mechanisms of coronary disease risk 64 samples

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