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A microglia clonal inflammatory disorder in Alzheimer’s Disease

GSE274037 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing 54 samples Submitted 2025/03/19 Platform GPL24247Platform GPL24676
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
A microglia clonal inflammatory disorder in Alzheimer's disease
Vicario R, Fragkogianni S, Weber L et al. · eLife 2025 · PMID 40085681 · doi:10.7554/eLife.96519
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE274037_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 54 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1144494 and SRA study SRP524385. Searching any of these in the dataset finder brings you back here.

Study design
12 conditions, mostly in triplicate
CBL WT 91 NT ×3 CBL WT 93 NT ×3 CBL HET C404Y 89 NT ×3 CBL HET C404Y 71 NT ×3 10H_CBL_C416S ×3 11H_CBL_I383M ×3 12E_RIT1 ×3 13E_RIT1_F99C ×3 +8 more

Supports a between-group comparison across 36 samples.

12 replicated groups read from the first 40 of 54 sample titles; they account for 36 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 14 more — browse all 54 samples with per-sample file links →

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