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Metabolic dysfunction-associated steatotic liver disease may increase intrahepatic interferon gene signatures in patients with chronic hepatitis B

GSE288077 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing 35 samples Submitted 2025/01/27 Platform GPL34284Platform GPL34290
Summary
As metabolic dysfunction-associated steatotic liver disease (MASLD) frequently co_x0002_occurs in patients with chronic hepatitis B (CHB), the interplay between these two common liver conditions remains largely unexplored. A recent study suggest that MASH comorbidity can reduce intrahepatic interferon pathway activity and macrophage gene signatures in HBeAg_x0002_negative chronic HBV (ENEG) patients, potentially contributing to persistent infection and fibrosis. However, it remains unclear whether this phenomenon also occurs in MASLD with CHB patients.
Published in
Metabolic dysfunction-associated steatotic liver disease may increase intrahepatic interferon gene signatures in patients with chronic hepatitis B
Han Y, Tang J, Hu P et al. · Journal of hepatology 2025 · PMID 39900119 · doi:10.1016/j.jhep.2025.01.036
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Direct links to NCBI, no account and no request form: the whole study as GSE288077_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 35 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1216006 and SRA study SRP560035. Searching any of these in the dataset finder brings you back here.

Study design
6 conditions, mostly with about 4 replicates each
EM ×11 E ×7 HBV ×5 HBV-MASLD ×4 Control ×4 MASLD ×4

Supports a between-group comparison across 35 samples.

6 replicated groups read from 35 sample titles; they account for 35 of them. Check it against the sample list below before relying on it.

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