GEO series
Senescent activated naive B cells promote anti-citrullinated antigen T cell responses and the transition to clinical rheumatoid arthritis
GSE342939
Homo sapiens
Other; Expression profiling by high throughput sequencing
78 samples
Submitted 2026/08/07
Platform GPL34284
Summary
This study profiles peripheral B cells from individuals at risk for rheumatoid arthritis (RA), including ACPA-positive converters to clinical RA, ACPA-positive non-converters, and healthy controls, at paired pre and post time points. Using 10x Genomics Chromium single-cell gene expression (scRNA-seq), antibody-derived tag / CITE-seq surface protein profiling, and B cell receptor (BCR) V(D)J sequencing, we characterize activated naive B cell states associated with progression toward clinical RA.
This dataset
Download
Direct links to NCBI, no account and no request form: the whole study as GSE342939_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 78 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1344838 and SRA study SRP632981. Searching any of these in the dataset finder brings you back here.
Study design
40 conditions, each sampled once — no replicated groups
Read from the first 40 of 78 sample titles: 40 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM9943404 Peripheral B cells, healthy control, pre, scRNA-seq, NN1A
- GSM9943405 Peripheral B cells, healthy control, pre, CITE-seq, NN1A
- GSM9943406 Peripheral B cells, healthy control, pre, BCR-seq, NN1A
- GSM9943407 Peripheral B cells, healthy control, post, scRNA-seq, NN1B
- GSM9943408 Peripheral B cells, healthy control, post, CITE-seq, NN1B
- GSM9943409 Peripheral B cells, healthy control, post, BCR-seq, NN1B
- GSM9943410 Peripheral B cells, healthy control, pre, scRNA-seq, NN2A
- GSM9943411 Peripheral B cells, healthy control, pre, CITE-seq, NN2A
- GSM9943412 Peripheral B cells, healthy control, pre, BCR-seq, NN2A
- GSM9943413 Peripheral B cells, healthy control, post, scRNA-seq, NN2B
- GSM9943414 Peripheral B cells, healthy control, post, CITE-seq, NN2B
- GSM9943415 Peripheral B cells, healthy control, post, BCR-seq, NN2B
- GSM9943416 Peripheral B cells, healthy control, pre, scRNA-seq, NN3A
- GSM9943417 Peripheral B cells, healthy control, pre, CITE-seq, NN3A
- GSM9943418 Peripheral B cells, healthy control, pre, BCR-seq, NN3A
- GSM9943419 Peripheral B cells, healthy control, post, scRNA-seq, NN3B
- GSM9943420 Peripheral B cells, healthy control, post, CITE-seq, NN3B
- GSM9943421 Peripheral B cells, healthy control, post, BCR-seq, NN3B
- GSM9943422 Peripheral B cells, ACPA-positive converter to clinical RA, pre, scRNA-seq, PC1A
- GSM9943423 Peripheral B cells, ACPA-positive converter to clinical RA, pre, CITE-seq, PC1A
- GSM9943424 Peripheral B cells, ACPA-positive converter to clinical RA, pre, BCR-seq, PC1A
- GSM9943425 Peripheral B cells, ACPA-positive converter to clinical RA, post, scRNA-seq, PC1B
- GSM9943426 Peripheral B cells, ACPA-positive converter to clinical RA, post, CITE-seq, PC1B
- GSM9943427 Peripheral B cells, ACPA-positive converter to clinical RA, post, BCR-seq, PC1B
- GSM9943428 Peripheral B cells, ACPA-positive converter to clinical RA, pre, scRNA-seq, PC2A
- GSM9943429 Peripheral B cells, ACPA-positive converter to clinical RA, pre, CITE-seq, PC2A
- GSM9943430 Peripheral B cells, ACPA-positive converter to clinical RA, pre, BCR-seq, PC2A
- GSM9943431 Peripheral B cells, ACPA-positive converter to clinical RA, post, scRNA-seq, PC2B
- GSM9943432 Peripheral B cells, ACPA-positive converter to clinical RA, post, CITE-seq, PC2B
- GSM9943433 Peripheral B cells, ACPA-positive converter to clinical RA, post, BCR-seq, PC2B
- GSM9943434 Peripheral B cells, ACPA-positive converter to clinical RA, pre, scRNA-seq, PC3A
- GSM9943435 Peripheral B cells, ACPA-positive converter to clinical RA, pre, CITE-seq, PC3A
- GSM9943436 Peripheral B cells, ACPA-positive converter to clinical RA, pre, BCR-seq, PC3A
- GSM9943437 Peripheral B cells, ACPA-positive converter to clinical RA, post, scRNA-seq, PC3B
- GSM9943438 Peripheral B cells, ACPA-positive converter to clinical RA, post, CITE-seq, PC3B
- GSM9943439 Peripheral B cells, ACPA-positive converter to clinical RA, post, BCR-seq, PC3B
- GSM9943440 Peripheral B cells, ACPA-positive converter to clinical RA, pre, scRNA-seq, PC4A
- GSM9943441 Peripheral B cells, ACPA-positive converter to clinical RA, pre, CITE-seq, PC4A
- GSM9943442 Peripheral B cells, ACPA-positive converter to clinical RA, pre, BCR-seq, PC4A
- GSM9943443 Peripheral B cells, ACPA-positive converter to clinical RA, post, scRNA-seq, PC4B
+ 38 more — browse all 78 samples with per-sample file links →
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