GEO series
CCR10-Regulated Mucosal Immune Responses Support Restoration of Lung Tissue Homeostasis after SARS-CoV-2 infection.
GSE334311
Mus musculus
Expression profiling by high throughput sequencing
9 samples
Submitted 2026/08/07
Platform GPL24247
Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. While most patients can clear the infection and recover, some develop severe symptoms associated with dysregulated immune activation that leads to injury of lungs. Clinical studies found that severities of COVID-19 patients correlated with levels of mucosa-homing CCR10+ immunoglobulin A (IgA) antibody-secreting cells (IgA-ASCs) while recovery was linked to expansion of CCR10+ type 2 innate lymphoid cells (ILC2s). However, exact roles of CCR10-regulated mucosal immune responses in SARS-CoV-2 infection and pathology are not clear. Here, we addressed these questions using CCR10-knockout (KO) mice infected with a mouse-adapted strain of SARS-CoV-2. SARS-CoV-2-infected CCR10-KO mice had reduced IgA-ASCs but increased ILCs and T cells in lungs compared to control wild-type (WT) mice. However, CCR10-KO mice cleared SARS-CoV-2 as efficiently as WT mice, suggesting that CCR10-regulated mucosal immune responses are not critical for viral clearance. On the other hand, CCR10-KO mice, particularly males, were impaired in recovery from SARS-CoV-2-induced lung damages due to the immune dysregulation. Intranasal immunization overcame defective mucosal immune responses and prevented SARS-CoV-2-induced lung pathology in CCR10-KO mice. Our results revealed an important role of CCR10-regulated mucosal immune responses in restoration of lung homeostasis after SARS-CoV-2 infection.
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE334311_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1474577 and SRA study SRP706608. Searching any of these in the dataset finder brings you back here.
Study design
9 conditions, each sampled once — no replicated groups
Read from 9 sample titles: 9 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
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- GSM9785249 CCR10 Het 1 Lung Tissue SARS-CoV-2 MA10 infected, Day 14
- GSM9785250 CCR10 Het 2 Lung Tissue SARS-CoV-2 MA10 infected, Day 14
- GSM9785251 CCR10 Het 3 Lung Tissue SARS-CoV-2 MA10 infected, Day 14
- GSM9785252 CCR10 Het 4 Lung Tissue SARS-CoV-2 MA10 infected, Day 14
- GSM9785253 CCR10 Het 5 Lung Tissue SARS-CoV-2 MA10 infected, Day 14
- GSM9785254 CCR10 KO 6 Lung Tissue SARS-CoV-2 MA10 infected, Day 14
- GSM9785255 CCR10 KO 7 Lung Tissue SARS-CoV-2 MA10 infected, Day 14
- GSM9785256 CCR10 KO 9 Lung Tissue SARS-CoV-2 MA10 infected, Day 14
- GSM9785257 CCR10 KO 10 Lung Tissue SARS-CoV-2 MA10 infected, Day 14
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