APOE genotype modifies the gene signature of microglial and astrocytic responses to aging

Direct links to NCBI, no account and no request form: the whole study as GSE285471_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 24 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1203890 and SRA study SRP554196. Searching any of these in the dataset finder brings you back here.

Supports a between-group comparison across 24 samples.

12 replicated groups read from 24 sample titles; they account for 24 of them. Check it against the sample list below before relying on it.

• GSM8702983 APOE2, Male, 3M, #1
• GSM8702984 APOE3, Male, 3M, #1
• GSM8702985 APOE4, Male, 3M, #1
• GSM8702986 APOE2, Male, 24M, #1
• GSM8702987 APOE3, Male, 24M, #1
• GSM8702988 APOE4, Male, 24M, #1
• GSM8702989 APOE2, Female, 3M, #1
• GSM8702990 APOE3, Female, 3M, #1
• GSM8702991 APOE4, Female, 3M, #1
• GSM8702992 APOE2, Female, 24M, #1
• GSM8702993 APOE3, Female, 24M, #1
• GSM8702994 APOE4, Female, 24M, #1
• GSM8702995 APOE2, Female, 3M, #2
• GSM8702996 APOE3, Female, 3M, #2
• GSM8702997 APOE4, Female, 3M, #2
• GSM8702998 APOE2, Female, 24M, #2
• GSM8702999 APOE3, Female, 24M, #2
• GSM8703000 APOE4, Female, 24M, #2
• GSM8703001 APOE2, Male, 3M, #2
• GSM8703002 APOE3, Male, 3M, #2
• GSM8703003 APOE4, Male, 3M, #2
• GSM8703004 APOE2, Male, 24M, #2
• GSM8703005 APOE3, Male, 24M, #2
• GSM8703006 APOE4, Male, 24M, #2

• GSE314817 Multi-tissue, multi-time-point transcriptomic atlas of aging in mice and rats [mouse] 2432 samples
• GSE334940 Tissue nanotransfection-mediated induction of neurogenic programs promotes myoprotective responses in denervated skeletal muscle 15 samples
• GSE300591 Temporal changes in metabolism guide oligodendrocyte precursor cell dynamics in aging and multiple sclerosis 15 samples
• GSE293709 Transcriptome analysis in the prefrontal cortex of different ASD mouse models treated with drug 1565 samples
• GSE294832 Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part10] 1000 samples
• GSE326100 scRNA-seq of mouse cochlea organoid cells 768 samples
• GSE331176 Phagosome-mediated activation of STING by purine and pyrimidine-based bacterial cyclic dinucleotides 380 samples
• GSE304862 Semaglutide and exercise synergy in obesity: preserving muscle mass and uncovering organ crosstalk 209 samples

Search all mouse RNA-seq datasets in GEO →