GEO series
Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells
GSE327424
Homo sapiens
Other; Expression profiling by high throughput sequencing
86 samples
Submitted 2026/04/08
Platform GPL34281Platform GPL34284Platform GPL30173
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
This dataset
Download
Direct links to NCBI, no account and no request form: the whole study as GSE327424_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 86 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1450687 and SRA study SRP689623. Searching any of these in the dataset finder brings you back here.
Study design
33 conditions, each sampled once — no replicated groups
Donor1 human monocyte-derived macrophages tre… ×2
Donor1 human monocyte-derived macrophages tre… ×2
Donor2 human monocyte-derived macrophages tre… ×2
Donor2 human monocyte-derived macrophages tre… ×2
Donor3 human monocyte-derived macrophages tre… ×2
Donor3 human monocyte-derived macrophages tre… ×2
Donor4 human monocyte-derived macrophages tre… ×2
Read from the first 40 of 86 sample titles: 33 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM9648641 Donor1, high TNF expression bin
- GSM9648642 Donor1, low TNF expression bin
- GSM9648643 Donor2, high TNF expression bin
- GSM9648644 Donor2, low TNF expression bin
- GSM9648645 Donor1, high CD80 expression bin
- GSM9648646 Donor1, low CD80 expression bin
- GSM9648647 Donor2, high CD80 expression bin
- GSM9648648 Donor2, low CD80 expression bin
- GSM9648649 Donor3, high CD80 expression bin
- GSM9648650 Donor3, low CD80 expression bin
- GSM9648651 Donor4, high CD80 expression bin
- GSM9648652 Donor4, low CD80 expression bin
- GSM9648653 Myeloid-library plasmid
- GSM9648654 TF-library plasmid
- GSM9649068 Donor1 untreated human monocyte-derived macrophages
- GSM9649069 Donor1 human monocyte-derived macrophages treated with non-target eVLP
- GSM9649070 Donor1 human monocyte-derived macrophages treated with CD81-targeting eVLP
- GSM9649071 Donor1 human monocyte-derived macrophages treated with CD45-targeting eVLP sgRNA1
- GSM9649072 Donor1 human monocyte-derived macrophages treated with CD45-targeting eVLP sgRNA2
- GSM9649073 Donor1 human monocyte-derived macrophages treated with CD14-targeting eVLP sgRNA1
- GSM9649074 Donor1 human monocyte-derived macrophages treated with CD14-targeting eVLP sgRNA2
- GSM9649075 Donor2 untreated human monocyte-derived macrophages
- GSM9649076 Donor2 human monocyte-derived macrophages treated with non-target eVLP
- GSM9649077 Donor2 human monocyte-derived macrophages treated with CD81-targeting eVLP
- GSM9649078 Donor2 human monocyte-derived macrophages treated with CD45-targeting eVLP sgRNA1
- GSM9649079 Donor2 human monocyte-derived macrophages treated with CD45-targeting eVLP sgRNA2
- GSM9649080 Donor2 human monocyte-derived macrophages treated with CD14-targeting eVLP sgRNA1
- GSM9649081 Donor2 human monocyte-derived macrophages treated with CD14-targeting eVLP sgRNA2
- GSM9649082 Donor3 untreated human monocyte-derived macrophages
- GSM9649083 Donor3 human monocyte-derived macrophages treated with non-target eVLP
- GSM9649084 Donor3 human monocyte-derived macrophages treated with CD81-targeting eVLP
- GSM9649085 Donor3 human monocyte-derived macrophages treated with CD45-targeting eVLP sgRNA1
- GSM9649086 Donor3 human monocyte-derived macrophages treated with CD45-targeting eVLP sgRNA2
- GSM9649087 Donor3 human monocyte-derived macrophages treated with CD14-targeting eVLP sgRNA1
- GSM9649088 Donor3 human monocyte-derived macrophages treated with CD14-targeting eVLP sgRNA2
- GSM9649089 Donor4 untreated human monocyte-derived macrophages
- GSM9649090 Donor4 human monocyte-derived macrophages treated with non-target eVLP
- GSM9649091 Donor4 human monocyte-derived macrophages treated with CD81-targeting eVLP
- GSM9649092 Donor4 human monocyte-derived macrophages treated with CD45-targeting eVLP sgRNA1
- GSM9649093 Donor4 human monocyte-derived macrophages treated with CD45-targeting eVLP sgRNA2
+ 46 more — browse all 86 samples with per-sample file links →
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