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Decoupling oxidative resilience from reprogramming to rejuvenate the RPE and restore vision

GSE304044 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 120 samples Submitted 2026/06/11 Platform GPL24676Platform GPL24247
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE304044_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 120 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1298805 and SRA study SRP604608. Searching any of these in the dataset finder brings you back here.

Study design
9 conditions, mostly with about 5 replicates each
15-months ×5 24-months ×5 15-months-OSK ×5 24-months-OSK ×5 15-months-OSK-onoff ×5 3-months ×4 3-months-OSK ×4 3-months-OSK-onoff ×4 +1 more

Supports a between-group comparison across 40 samples.

9 replicated groups read from the first 40 of 120 sample titles; they account for 40 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 80 more — browse all 120 samples with per-sample file links →

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