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PRMT1 recruitment and H4R3Me2a modification in control and PRMT1-depleted trophoblast progenitor

GSE295846 Homo sapiens; Mus musculus Genome binding/occupancy profiling by high throughput sequencing 25 samples Submitted 2026/06/15 Platform GPL24247Platform GPL24676
Summary
To understand PRMT1 recruitment and associated changes in histone H4 arginine3 di-methylation at the chromatin region in trophoblast progenitors, we performed CUT&RUN experiments in CT27 human trophoblast stem cells (CT27 hTSCs) and in primary trophoblast stem and progenitor cells (TSPCs) in mouse embryonic day (E) 7.5 ectoplacental cone region (EPC). For CT27 hTSCs, experiments were done in both control and PRMT1-knockdown CT27 hTSC. We also tested RNA polymerase II recruitment in these cells.
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Direct links to NCBI, no account and no request form: the whole study as GSE295846_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 25 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1256477 and SRA study SRP581955. Searching any of these in the dataset finder brings you back here.

Study design
25 conditions, each sampled once — no replicated groups

Read from 25 sample titles: 25 distinct titles with little repetition. Check it against the sample list below before relying on it.

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