Direct measurement of RNA Polymerase II hypertranscription in cancer FFPE samples

Direct links to NCBI, no account and no request form: the whole study as GSE261351_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 278 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1086538 and SRA study SRP494607. Searching any of these in the dataset finder brings you back here.

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• GSE245731 HNF4G and FOXA1 are context-specific drivers of pancreatic cancer progression [ChIP-seq] 172 samples
• GSE269652 SP1 antagonizes H3K27me3 to shape chromatin landscapes for RNA polymerase II recruitment during gastrulation 106 samples
• GSE292300 A core transcriptional regulatory circuitry controls super-enhancer-driven activation of LGR5 in colorectal cancer: ChIP-seq 76 samples
• GSE254753 Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors (ATAC-Seq) 45 samples
• GSE289247 Crosstalk between the polycomb repressive complex 2 and DNA methylation mediates neuroendocrine prostate cancer lineage plasticity [ChIP-Seq] 35 samples
• GSE270774 MYC couples SWI/SNF and metabolic reprogramming to sustain minimal residual disease in mTORC1-activated cancer cells [CUT&RUN, ATAC-seq] 32 samples
• GSE297358 Loss of NOTCH2 Creates a TRIM28-Dependent Vulnerability in Small Cell Lung Cancer [ChIP-seq] 29 samples
• GSE267775 KMT2C Deficiency Drives Luminal Transdifferentiation into Double-Negative Prostate Cancer and Sensitizes to Fatty Acid Synthase Inhibition [CUT&Tag] 26 samples

Search all ChIP / ATAC / CUT&Tag datasets in GEO →