GEO series
EZH2 inhibitor SHR2554 enhances the anti-tumor efficacy of HDAC inhibitor Chidamide through STAT1 in T-cell lymphoma
GSE293546
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
34 samples
Submitted 2026/04/30
Platform GPL20301
Summary
T-cell lymphoma (TCL) is a rare subtype of non-Hodgkin lymphoma (NHL) that is associated with a poor prognosis. Although HDAC inhibitors have been approved for TCL treatment for several years, their expected therapeutic efficacy remains unmet in some patients. In this study, we discovered that TCL tumor cells develop resistance to HDAC inhibitor treatment by upregulating the methylation of lysine 27 on histone H3 (H3K27me3) levels. Furthermore, we confirmed the pharmacological efficacy of the EZH2 inhibitor SHR2554 and demonstrated a synergistic effect when combined with the HDAC inhibitor Chidamide through commercial T-cell lymphoma cell lines, in vivo cell-derived xenograft, and patient-derived xenograft cancer models. We inferred that STAT1 was the key driver of the synergy effect using RNA-seq and ChIP-seq analysis. Our findings provide sufficient preclinical evidence in support of a potential combination therapy strategy for TCL patients.
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE293546_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 34 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1245163 and SRA study SRP575907. Searching any of these in the dataset finder brings you back here.
Study design
25 conditions, each sampled once — no replicated groups
H9_CT ×3
H9 ×3
H9_SHR5 ×3
H9_CHI0.2 ×2
H9_SHR8 ×2
H9_COMBO8-0_2 ×2
Read from 34 sample titles: 25 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM8884939 H9_CT
- GSM8884940 H9_CT-1
- GSM8884941 H9_CT-2
- GSM8884942 H9_CHI0.2
- GSM8884943 H9_CHI0.2-1
- GSM8884944 H9_CHI0.2-2
- GSM8884945 H9_SHR8
- GSM8884946 H9_SHR8-1
- GSM8884947 H9_SHR8-2
- GSM8884948 H9_COMBO8-0_2
- GSM8884949 H9_COMBO8-0_2-1
- GSM8884950 H9_COMBO8-0_2-2
- GSM8884951 H9-1
- GSM8884952 H9-2
- GSM8884953 H9-3
- GSM8884954 H9_SHR5-1
- GSM8884955 H9_SHR5-2
- GSM8884956 H9_SHR5-3
- GSM8884957 CT1_IP
- GSM8884958 CT2_IP
- GSM8884959 CT3_IP
- GSM8884960 CHI1_IP
- GSM8884961 CHI2_IP
- GSM8884962 CHI3_IP
- GSM8884963 SHR1_IP
- GSM8884964 SHR2_IP
- GSM8884965 SHR3_IP
- GSM8884966 COMBO1_IP
- GSM8884967 COMBO2_IP
- GSM8884968 COMBO3_IP
- GSM8884969 CT_INPUT
- GSM8884970 CHI_INPUT
- GSM8884971 SHR_INPUT
- GSM8884972 COMBO_INPUT
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