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Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptic remodeling in the inflamed brain [snRNA-Seq]

GSE289109 Mus musculus; Homo sapiens Expression profiling by high throughput sequencing 20 samples Submitted 2025/12/23 Platform GPL24247Platform GPL24676
Summary
Our study provides novel evidence that neuronal intrinsic epigenetic changes are established as a consequence of cytotoxic T cell-mediated immune attacks and persist long after the resolution of the inflammatory process and associate to long lasting synaptic loss
Published in
Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptopathy in encephalitis
Shammas G, Piccinno M, Egervari K et al. · Neuron 2026 · PMID 41448185 · doi:10.1016/j.neuron.2025.11.006
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Direct links to NCBI, no account and no request form: the whole study as GSE289109_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 20 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1221549 and SRA study SRP562713. Searching any of these in the dataset finder brings you back here.

Study design
7 conditions, mostly in duplicate
RasmussenEncephalitisHC_NeuNpos_Patient ×2 CNCHCNEG ×2 CNCHCPOS ×2 CC10HCNEG ×2 CC10HCPOS ×2 CC70HCNEG ×2 CC70HCPOS ×2 CC10HC ×1 +5 more

Supports a between-group comparison across 14 samples.

7 replicated groups read from 20 sample titles; they account for 14 of them. Check it against the sample list below before relying on it.

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