GEO series
Human microglia reduce alpha-synuclein aggregation and are neuroprotective in adult mouse brain
GSE298706
Mus musculus; Homo sapiens
Expression profiling by high throughput sequencing
24 samples
Submitted 2025/09/04
Platform GPL35012
Summary
Microglia, brain-resident immune cells, are involved in pathophysiology of several neurodegenerative diseases, including Parkinson’s disease. Given significant species-specific differences in microglia gene expression, particularly in disease-risk genes, as well as the highly reactive nature of these cells, studying human microglia in a whole brain environment is essential. Here, we established a humanized mouse model by transplanting human induced pluripotent stem cell-derived hematopoietic progenitor cells into the striatum of immunodeficient adult mice and injected human alpha-synuclein preformed fibrils to model Parkinson’s disease pathology. We aimed to create a novel model of Parkinson's disease and studied the response of the human microglia and mouse cells to the preformed fibrils.
Published in
Albert K, Peltonen S, Vanne A et al.
· Brain, behavior, and immunity 2025
· PMID 40912593
· doi:10.1016/j.bbi.2025.106097
This dataset
Download
Direct links to NCBI, no account and no request form: the whole study as GSE298706_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 24 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1270983 and SRA study SRP589444. Searching any of these in the dataset finder brings you back here.
Study design
24 conditions, each sampled once — no replicated groups
Read from 24 sample titles: 24 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM9021258 52L, Mouse STR LEFT, male, MG-, SAL
- GSM9021259 52R, Mouse STR RIGHT, male, MG+, SAL
- GSM9021260 53L, Mouse STR LEFT, male, MG+, no treatment
- GSM9021261 53R, Mouse STR RIGHT, male, MG-, PFF
- GSM9021262 55L, Mouse STR LEFT, male, MG-, SAL
- GSM9021263 55R, Mouse STR RIGHT, male, MG+, SAL
- GSM9021264 56L, Mouse STR LEFT, female, MG+, no treatment
- GSM9021265 56R, Mouse STR RIGHT, female, MG-, PFF
- GSM9021266 57L, Mouse STR LEFT, female, MG-, PFF
- GSM9021267 57R, Mouse STR RIGHT, female, MG+, PFF
- GSM9021268 58L, Mouse STR LEFT, female, MG-, SAL
- GSM9021269 58R, Mouse STR RIGHT, female, MG+, SAL
- GSM9021270 59L, Mouse STR LEFT, female, MG-, no treatment
- GSM9021271 59R, Mouse STR RIGHT, female, MG+, PFF
- GSM9021272 63L, Mouse STR LEFT, female, MG-, PFF
- GSM9021273 63R, Mouse STR RIGHT, female, MG+, PFF
- GSM9021274 65L, Mouse STR LEFT, female, MG-, no treatment
- GSM9021275 65R, Mouse STR RIGHT, female, MG+, PFF
- GSM9021276 70L, Mouse STR LEFT, female, MG-, no treatment
- GSM9021277 70R, Mouse STR RIGHT, female, MG+, PFF
- GSM9021278 77L, Mouse STR LEFT, male, MG-, no treatment
- GSM9021279 77R, Mouse STR RIGHT, male, MG+, PFF
- GSM9021280 82L, Mouse STR LEFT, female, MG-, no treatment
- GSM9021281 83R, Mouse STR RIGHT, female, sham, PFF
Similar datasets
- GSE277025 Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy 192 samples
- GSE285838 Histone chaperon ASF1B recruits distinct epigenetic factors in regulation of histone variant H3.3 during the fetal and adult erythropoiesis II 26 samples
- GSE289109 Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptic remodeling in the inflamed brain [snRNA-Seq] 20 samples
- GSE260997 Mutant IDH inhibitors induce lineage differentiation in IDH-mutant Oligodendroglioma III 2458 samples
- GSE202126 Single-cell Total-RNA Profiling Unveils Regulatory Hubs of Transcription Factors 1089 samples
- GSE307112 Mapping the Dialogue: Decoding Alveolar Stem-Niche Interactions [I] 886 samples
- GSE327497 Localized PD-1 CAR T therapy reprograms neuroinflammation. 390 samples
- GSE289991 Persistent dopamine-dependent remodeling of the neural transcriptome in response to pregnancy and postpartum [bulk RNA-seq] 294 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.