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Nitric oxide drives proteomic diversity through alternative splicing

GSE286557 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing 44 samples Submitted 2026/05/21 Platform GPL21697Platform GPL34328
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Nitric oxide drives proteomic diversity through alternative splicing
Schindler JC, Seth P, Hausladen A et al. · Molecular cell 2026 · PMID 42167237 · doi:10.1016/j.molcel.2026.04.024
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE286557_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 44 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1209902 and SRA study SRP556966. Searching any of these in the dataset finder brings you back here.

Study design
7 conditions, mostly with about 4 replicates each
WT PTB (flox) + cytokines, biol ×4 C250S PTB + cytokines, biol ×4 WT PTB (flox), untreated, biol ×4 C250S PTB, untreated, biol ×4 WT PTB + NOS1, biol ×3 C251S PTB + NOS1, biol ×3 WT PTB + empty vector, biol ×2 WT PTB + NOS1, biol rep 1 (input) ×1 +15 more

Supports a between-group comparison across 24 samples.

7 replicated groups read from the first 40 of 44 sample titles; they account for 24 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 4 more — browse all 44 samples with per-sample file links →

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