GEO series
Whole transcriptome analysis reveals T cell signaling activation in septic patients with thrombocytopenia
GSE273700
Homo sapiens
Expression profiling by high throughput sequencing
104 samples
Submitted 2026/01/28
Platform GPL24676
Summary
Sepsis, a life-threatening condition triggered by a dysregulated immune response to infection, remains one of the leading causes of mortality worldwide. Thrombocytopenia, a common sepsis complication, is linked to poor outcomes and reflects disease severity and specific immunological changes affecting patient outcomes. This study aims to elucidate this relationship using whole-transcriptome RNA sequencing (RNA-Seq) in intensive care unit (ICU) patients with sepsis.
Published in
Chen IC, Jiang YH, Hsiao TH et al.
· Scientific reports 2025
· PMID 41444326
· doi:10.1038/s41598-025-32584-9
This dataset
Download
Direct links to NCBI, no account and no request form: the whole study as GSE273700_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 104 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1142876 and SRA study SRP523568. Searching any of these in the dataset finder brings you back here.
Study design
40 conditions, each sampled once — no replicated groups
Read from the first 40 of 104 sample titles: 40 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM8435561 RICU190827-1_001A [Thrombocytopenia(+)]
- GSM8435562 RICU190903-1_002A [Thrombocytopenia(+)]
- GSM8435563 RICU200410-1_001A [Thrombocytopenia(+)]
- GSM8435564 RICU200417-1_002A [Thrombocytopenia(+)]
- GSM8435565 RICU200824-1_001A [Thrombocytopenia(+)]
- GSM8435566 RICU200901-2_002A [Thrombocytopenia(+)]
- GSM8435567 RICU200902-1_001A [Thrombocytopenia(+)]
- GSM8435568 RICU200909-1_002A [Thrombocytopenia(+)]
- GSM8435569 RICU201021-1_001A [Thrombocytopenia(+)]
- GSM8435570 RICU201028-1_002A [Thrombocytopenia(+)]
- GSM8435571 RICU201029-1_001A [Thrombocytopenia(+)]
- GSM8435572 RICU201105-1_002A [Thrombocytopenia(+)]
- GSM8435573 RICU201201-2_001A [Thrombocytopenia(+)]
- GSM8435574 RICU201208-2_002A [Thrombocytopenia(+)]
- GSM8435575 RICU210429-2_001A [Thrombocytopenia(+)]
- GSM8435576 RICU210504-1_002A [Thrombocytopenia(+)]
- GSM8435577 RICU210520-1_001A [Thrombocytopenia(+)]
- GSM8435578 RICU210527-1_002A [Thrombocytopenia(+)]
- GSM8435579 RICU211026-1_001A [Thrombocytopenia(+)]
- GSM8435580 RICU211102-1_002A [Thrombocytopenia(+)]
- GSM8435581 RICU211124-1_001A [Thrombocytopenia(+)]
- GSM8435582 RICU211130-2_001A [Thrombocytopenia(+)]
- GSM8435583 RICU211201-1_002A [Thrombocytopenia(+)]
- GSM8435584 RICU211201-3_001A [Thrombocytopenia(+)]
- GSM8435585 RICU211208-2_002A [Thrombocytopenia(+)]
- GSM8435586 RICU211208-3_002A [Thrombocytopenia(+)]
- GSM8435587 RICU211214-1_001A [Thrombocytopenia(+)]
- GSM8435588 RICU211221-1_002A [Thrombocytopenia(+)]
- GSM8435589 RICU211227-1_001A [Thrombocytopenia(+)]
- GSM8435590 RICU211228-2_001A [Thrombocytopenia(+)]
- GSM8435591 RICU220103-1_002A [Thrombocytopenia(+)]
- GSM8435592 RICU220104-1_002A [Thrombocytopenia(+)]
- GSM8435593 RICU220121-3_001A [Thrombocytopenia(+)]
- GSM8435594 RICU220126-3_002A [Thrombocytopenia(+)]
- GSM8435595 RICU220210-1_001A [Thrombocytopenia(+)]
- GSM8435596 RICU220216-1_002A [Thrombocytopenia(+)]
- GSM8435597 RICU220225-1_001A [Thrombocytopenia(+)]
- GSM8435598 RICU220301-1_002A [Thrombocytopenia(+)]
- GSM8435599 RICU220316-1_001A [Thrombocytopenia(+)]
- GSM8435600 RICU220324-1_002A [Thrombocytopenia(+)]
+ 64 more — browse all 104 samples with per-sample file links →
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