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Transcriptome profile of hepatocellular carcinoma in patients with atezolizumab plus bevacizumab therapy.

GSE285963 Homo sapiens Expression profiling by high throughput sequencing 84 samples Submitted 2025/10/02 Platform GPL24676
Summary
Hepatocellular carcinoma (HCC) is a rapidly increasing and highly lethal cancer worldwide, with many patients diagnosed at advanced stages and early-stage patients often experiencing high recurrence rates. The combination of atezolizumab plus bevacizumab emerged as a groundbreaking immunotherapy, establishing a new standard of care for advanced HCC. There's an urgent need for reliable biomarkers to predict patient responses and personalize treatment. We collected tumor samples from advanced HCC patients wirth atezolizumab plus bevacizumab therapy and performed comprehensive analyses of the tumor microenvironment using bulk RNA sequencing to identify key features influencing the effectiveness of atezolizumab plus bevacizumab.
Published in
The efficacy of atezolizumab plus bevacizumab for advanced hepatocellular carcinoma in relation to tumor-infiltrating lymphocytes
Kanzaki H, Ishino T, Ogasawara S et al. · JHEP reports : innovation in hepatology 2025 · PMID 41362708 · doi:10.1016/j.jhepr.2025.101614
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE285963_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 84 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1207067 and SRA study SRP555581. Searching any of these in the dataset finder brings you back here.

Study design
40 conditions, each sampled once — no replicated groups

Read from the first 40 of 84 sample titles: 40 distinct titles with little repetition. Check it against the sample list below before relying on it.

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