GEO series
Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in synovial sarcoma
GSE266135
Homo sapiens; Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
90 samples
Submitted 2025/08/06
Platform GPL24247Platform GPL24676
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Floros KV, Fairchild CK Jr, Li J et al.
· Nature communications 2025
· PMID 41193430
· doi:10.1038/s41467-025-64665-8
This dataset
Download
Direct links to NCBI, no account and no request form: the whole study as GSE266135_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 90 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1105952 and SRA study SRP504481. Searching any of these in the dataset finder brings you back here.
Study design
9 conditions, mostly in triplicate
SSX, ChIP, treated ×6
SSX, ChIP, untreated ×6
HS-SY-II, SMARCA4, ChIP, treated ×5
HS-SY-II, SMARCA4, ChIP, untreated ×5
HS-SY-II, KDM2B (JHDM1B), ChIP, treated ×3
HS-SY-II, KDM2B (JHDM1B), ChIP, untreated ×3
SYO-1, KDM2B (JHDM1B), ChIP, treated ×3
SYO-1, KDM2B (JHDM1B), ChIP, untreated ×3
+5 more
Supports a between-group comparison across 36 samples.
9 replicated groups read from the first 40 of 90 sample titles; they account for 36 of them. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM8240020 HS-SY-II, SMARCA4, ChIP, input
- GSM8240021 HS-SY-II, SMARCA4, ChIP, treated1
- GSM8240022 HS-SY-II, SMARCA4, ChIP, treated2
- GSM8240023 HS-SY-II, SMARCA4, ChIP, treated3
- GSM8240024 HS-SY-II, SMARCA4, ChIP, treated4
- GSM8240025 HS-SY-II, SMARCA4, ChIP, treated5
- GSM8240026 HS-SY-II, SMARCA4, ChIP, untreated1
- GSM8240027 HS-SY-II, SMARCA4, ChIP, untreated2
- GSM8240028 HS-SY-II, SMARCA4, ChIP, untreated3
- GSM8240029 HS-SY-II, SMARCA4, ChIP, untreated4
- GSM8240030 HS-SY-II, SMARCA4, ChIP, untreated5
- GSM8240046 HS-SY-II, SS18::SSX, ChIP, input
- GSM8240047 HS-SY-II, SS18::SSX, ChIP, treated 1
- GSM8240048 HS-SY-II, SS18::SSX, ChIP, treated 2
- GSM8240049 HS-SY-II, SS18::SSX, ChIP, treated 3
- GSM8240050 HS-SY-II, SS18::SSX, ChIP, untreated 1
- GSM8240051 HS-SY-II, SS18::SSX, ChIP, untreated 2
- GSM8240052 HS-SY-II, SS18::SSX, ChIP, untreated 3
- GSM8240053 HS-SY-II, KDM2B (JHDM1B), ChIP, input
- GSM8240054 HS-SY-II, KDM2B (JHDM1B), ChIP, treated 1
- GSM8240055 HS-SY-II, KDM2B (JHDM1B), ChIP, treated 2
- GSM8240056 HS-SY-II, KDM2B (JHDM1B), ChIP, treated 3
- GSM8240057 HS-SY-II, KDM2B (JHDM1B), ChIP, untreated 1
- GSM8240058 HS-SY-II, KDM2B (JHDM1B), ChIP, untreated 2
- GSM8240059 HS-SY-II, KDM2B (JHDM1B), ChIP, untreated 3
- GSM8240060 SYO.1, SS18::SSX, ChIP, input
- GSM8240061 SYO.1, SS18::SSX, ChIP, treated 1
- GSM8240062 SYO.1, SS18::SSX, ChIP, treated 2
- GSM8240063 SYO.1, SS18::SSX, ChIP, treated 3
- GSM8240064 SYO.1, SS18::SSX, ChIP, untreated 1
- GSM8240065 SYO.1, SS18::SSX, ChIP, untreated 2
- GSM8240066 SYO.1, SS18::SSX, ChIP, untreated 3
- GSM8240067 SYO-1, KDM2B (JHDM1B), ChIP, input
- GSM8240068 SYO-1, KDM2B (JHDM1B), ChIP, treated 1
- GSM8240069 SYO-1, KDM2B (JHDM1B), ChIP, treated 2
- GSM8240070 SYO-1, KDM2B (JHDM1B), ChIP, treated 3
- GSM8240071 SYO-1, KDM2B (JHDM1B), ChIP, untreated 1
- GSM8240072 SYO-1, KDM2B (JHDM1B), ChIP, untreated 2
- GSM8240073 SYO-1, KDM2B (JHDM1B), ChIP, untreated 3
- GSM8241310 SYO.1, Atac seq, treated 1
+ 50 more — browse all 90 samples with per-sample file links →
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