GEO series

BCR::ABL1-induced enhancer reprogramming uncovers hypersensitivity of Ph+B-ALL cells to enhancer-targeting drugs [ChIP-Seq]

GSE279644 Homo sapiens; Mus musculus Genome binding/occupancy profiling by high throughput sequencing 91 samples Submitted 2026/02/27 Platform GPL21103Platform GPL20301

Summary

To better understand how BCR::ABL1 establishes the Ph+B-ALL-defining transcriptional program, we adopted an integrative multi-omics approach to study the transcriptome, enhancer activities, and 3-dimensional interactions of enhancers with target genes in Ph+B-ALL cells. We performed an in-depth analysis of cells from human Ph+B-ALL patients and a murine Ph+B-ALL model using ChIP-Seq, RNA-Seq, and Hi-C-based methods to link enhancers to the promoters they regulate. We further interfered with enhancer function to explore their role in Ph+B-ALL and investigated BCR::ABL1-regulated TFs that are recruited to them using targeted proteasomal degradation and RNA interference (RNAi).

Published in

BCR::ABL1-Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B-ALL Cells to Enhancer-Targeting Drugs

Ng HL, Glaser TL, Zhu J et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 · PMID 41764406 · doi:10.1002/advs.202517231

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Direct links to NCBI, no account and no request form: the whole study as GSE279644_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 91 samples. Raw sequencing reads are also available from ENA.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗ Raw reads on ENA ↗

Also filed as BioProject PRJNA1173753 and SRA study SRP538975. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41764406) ↗

Study design

31 conditions, each sampled once — no replicated groups

BA_p190_DMSO_H3K27ac ×3 BA_p190_PON_H3K27ac ×3 EV_D3_H3K27ac ×3 BCR_D60 ×3 EV_D7 ×2

Read from the first 40 of 91 sample titles: 31 distinct titles with little repetition. Check it against the sample list below before relying on it.

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