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Disruption of RNAPII transcription elongation links Oncogenic splicing factor mutations to replciation stress and targetable alterations in chromatin landscape [ATAC-seq]

GSE225993 Homo sapiens; Mus musculus Genome binding/occupancy profiling by high throughput sequencing 16 samples Submitted 2024/03/12 Platform GPL16791Platform GPL17021
Summary
To investigate changes in chromatin landscape and nucleosome positioning in response to SF3B1 mutations, we peformed ATAC seq in K562, human CD34, and murine cKit+,Sca1+,Lin- cells We then performed peak-based and nucleosome positioning analyses using data obtained from ATAC to investigate changes in chromatin accessibility and promoter nucleosome occupancy, respectively
Published in
Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
Boddu PC, Gupta AK, Roy R et al. · Molecular cell 2024 · PMID 38521065 · doi:10.1016/j.molcel.2024.02.032
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Also filed as BioProject PRJNA939532 and SRA study SRP425041. Searching any of these in the dataset finder brings you back here.

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