GEO series
Persistent dopamine-dependent remodeling of the neural transcriptome in response to pregnancy and postpartum [CUT&RUN]
GSE298543
Homo sapiens; Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
88 samples
Submitted 2026/04/13
Platform GPL34281Platform GPL34328
Summary
Pregnancy and postpartum experiences represent transformative physiological states that impose lasting demands on the maternal body and brain, resulting in lifelong neural adaptations. However, the precise molecular mechanisms driving these persistent alterations remain poorly understood. Here, we used brain-wide transcriptomic profiling to define the molecular landscape of parity-induced neural plasticity, identifying the dorsal hippocampus (dHpc) as a key site of transcriptional remodeling. Combining single-cell RNA sequencing with a maternal separation paradigm, we additionally demonstrated that chronic postpartum stress significantly disrupts dHpc adaptations by altering dopamine dynamics, leading to dysregulated transcription, altered cellular plasticity, and impaired behavior. We further established the sufficiency of dopamine modulation in the regulation of these parity-induced adaptations via chemogenetic suppression of dopamine release into dHpc, which recapitulated key transcriptional and behavioral features of parity in virgin females. In sum, our findings establish dopamine as a central regulator of parity-induced neuroadaptations, revealing a fundamental transcriptional mechanism by which female reproductive experiences remodel the maternal brain to sustain long-term behavioral adaptations.
Published in
O'Chan JC, Di Salvo G, Cunningham AM et al.
· Nature 2026
· PMID 42162419
· doi:10.1038/s41586-026-10509-4
This dataset
Download
Direct links to NCBI, no account and no request form: the whole study as GSE298543_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 88 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1269803 and SRA study SRP588814. Searching any of these in the dataset finder brings you back here.
Study design
40 conditions, each sampled once — no replicated groups
Read from the first 40 of 88 sample titles: 40 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM9016788 192_H3K4me3Q5dop
- GSM9016789 194_H3K4me3Q5dop
- GSM9016790 198_H3K4me3Q5dop
- GSM9016791 206_H3K4me3Q5dop
- GSM9016792 196_H3K4me3Q5dop
- GSM9016793 203_H3K4me3Q5dop
- GSM9016794 210_H3K4me3Q5dop
- GSM9016795 213_H3K4me3Q5dop
- GSM9016796 NP10_H3K4me3Q5dop
- GSM9016797 NP11_H3K4me3Q5dop
- GSM9016798 NP12_H3K4me3Q5dop
- GSM9016799 NP9_H3K4me3Q5dop
- GSM9016800 192_IgG
- GSM9016801 194_IgG
- GSM9016802 198_IgG
- GSM9016803 206_IgG
- GSM9016804 196_IgG
- GSM9016805 203_IgG
- GSM9016806 210_IgG
- GSM9016807 213_IgG
- GSM9016808 NP10_IgG
- GSM9016809 NP11_IgG
- GSM9016810 NP12_IgG
- GSM9016811 NP9_IgG
- GSM9016812 755_H3K4me3Q5dop
- GSM9016813 757_H3K4me3Q5dop
- GSM9016814 760_H3K4me3Q5dop
- GSM9016815 767_H3K4me3Q5dop
- GSM9016816 768_H3K4me3Q5dop
- GSM9016817 774_H3K4me3Q5dop
- GSM9016818 776_H3K4me3Q5dop
- GSM9016819 777_H3K4me3Q5dop
- GSM9016820 755_IgG
- GSM9016821 757_IgG
- GSM9016822 760_IgG
- GSM9016823 767_IgG
- GSM9016824 768_IgG
- GSM9016825 774_IgG
- GSM9016826 776_IgG
- GSM9016827 777_IgG
+ 48 more — browse all 88 samples with per-sample file links →
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