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NSD2 Degradation Remediates the Oncogenic Cistrome in t(4;14) Multiple Myeloma

GSE328217 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing 46 samples Submitted 2026/07/15 Platform GPL30173Platform GPL24676
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Summary
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Published in
NSD2 Degradation Remediates the Oncogenic Cistrome in t(4;14) Multiple Myeloma
Hu B, Edwards J, Modi H et al. · Blood 2026 · PMID 42371798 · doi:10.1182/blood.2025031998
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE328217_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 46 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1454367 and SRA study SRP692363. Searching any of these in the dataset finder brings you back here.

Study design
17 conditions, mostly in duplicate
KMS11_DMSO_Dup1_Day ×2 KMS11_DMSO_Dup2_Day ×2 KMS11_NSD2LDD_Dup1_Day ×2 KMS11_NSD2LDD_Dup2_Day ×2 KMS34_DMSO_Dup1_Day ×2 KMS34_DMSO_Dup2_Day ×2 KMS34_NSD2LDD_Dup1_Day ×2 KMS34_NSD2LDD_Dup2_Day ×2 +15 more

Supports a between-group comparison across 34 samples.

17 replicated groups read from the first 40 of 46 sample titles; they account for 34 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 6 more — browse all 46 samples with per-sample file links →

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