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CK2-mediated DEK Phosphorylation Drives PBX3 Overexpression: A Core Event in Hematopoietic Stem Cell-to-Leukemia Stem Cell Transformation

GSE309285 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 53 samples Submitted 2025/09/30 Platform GPL24247Platform GPL24676
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Phosphorylated DEK sustains leukemia stem cells by enabling PBX3-driven transcriptional reprogramming
Lei Y, Lai Y, Li Y et al. · Blood 2026 · PMID 42378254 · doi:10.1182/blood.2025032710
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE309285_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 53 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1335085 and SRA study SRP627107. Searching any of these in the dataset finder brings you back here.

Study design
15 conditions, mostly in duplicate
L-GMP_FL ×4 L-GMP_KO ×4 ATAC_L-GMP_FL ×3 ATAC_L-GMP_KO ×3 CUT-Tag_L-GMP_WT_DEK ×3 CUT-Tag_L-GMP_WT_PBX3 ×2 CUT-Tag_L-GMP_WT_GABPA ×2 CUT-Tag_L-GMP_KO_GABPA ×2 +10 more

Supports a between-group comparison across 37 samples.

15 replicated groups read from the first 40 of 53 sample titles; they account for 37 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 13 more — browse all 53 samples with per-sample file links →

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