GEO series
Reprogramming lineage features promotes epithelial behavior in carcinoma cells [ChIP-Seq]
GSE308983
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
23 samples
Submitted 2026/08/06
Platform GPL16791
Summary
Cancer cells distort epigenetic control of gene expression, allowing for a remarkable degree of plasticity and loss of cell type identity. At the same time, expression of identity-discordant lineage determinants can significantly shift cell phenotype by creating lineage hybrid states. One example is the misexpression of IKZF3, encoding the lymphocyte restricted transcription factor Aiolos, by roughly half of non-small cell lung carcinomas (NSCLC) and the majority of small cell lung carcinomas [1]. During normal lymphocyte development, pre-B progenitors enter a proliferative phase dependent on survival cues from bone marrow stroma. To progress, Aiolos and its paralog Ikaros (IKZF1) repress multiple adhesion-related genes, releasing cells from this epithelial-type dependence on solid matrix in preparation for their release as mature lymphocytes into the circulation [2, 3]. In lung cancers, unlicensed expression of Aiolos initiates a similar shift from an epithelial to a lymphocyte-like state by repression of multiple adhesion-related genes, resulting in loss of anoikis and consequent metastatic spread [1]. To reverse these lymphoid traits, we created a chimeric epigenetic editor designed to specifically retrieve Aiolos-repressed epithelial adhesion properties. Here, we demonstrate proof of principle for epithelial lineage restoration by exploiting a lymphocyte developmental pathway.
Published in
Wu RF, Fu G, Liao C et al.
· Cancer letters 2026
· PMID 41192784
· doi:10.1016/j.canlet.2025.218117
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE308983_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 23 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1333529 and SRA study SRP625646. Searching any of these in the dataset finder brings you back here.
Study design
23 conditions, each sampled once — no replicated groups
Read from 23 sample titles: 23 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
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- GSM9257761 control bio rep 1, H3K27ac ChIP
- GSM9257762 control bio rep 1, H3K27me3 ChIP
- GSM9257763 control bio rep 1, input
- GSM9257764 TA bio rep 1, H3K27ac ChIP
- GSM9257765 TA bio rep 1, HA ChIP
- GSM9257766 TA bio rep 1, H3K27me3 ChIP
- GSM9257767 TA bio rep 1, input
- GSM9257768 control bio rep 2, H3K27ac ChIP
- GSM9257769 control bio rep 2, Aiolos ChIP
- GSM9257770 control bio rep 2, H3K27me3 ChIP
- GSM9257771 control bio rep 2, input
- GSM9257772 TA bio rep 2, H3K27ac ChIP
- GSM9257773 TA bio rep 2, HA ChIP
- GSM9257774 TA bio rep 2, H3K27me3 ChIP
- GSM9257775 TA bio rep 2, input
- GSM9257776 control bio rep 3, H3K27ac ChIP
- GSM9257777 control bio rep 3, Aiolos ChIP
- GSM9257778 control bio rep 3, H3K27me3 ChIP
- GSM9257779 control bio rep 3, input
- GSM9257780 TA bio rep 3, H3K27ac ChIP
- GSM9257781 TA bio rep 3, HA ChIP
- GSM9257782 TA bio rep 3, H3K27me3 ChIP
- GSM9257783 TA bio rep 3, input
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