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Single cell 10X Genomics Multiome Analysis of H3.3K4M Mutant Brain Samples

GSE293881 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 32 samples Submitted 2025/07/14 Platform GPL24247
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Reducing methylation of histone 3.3 lysine 4 in the medial ganglionic eminence and hypothalamus recapitulates neurodevelopmental disorder phenotypes
Li J, Tanzillo AF, Pizzirusso G et al. · Nature communications 2026 · PMID 41720771 · doi:10.1038/s41467-026-69248-9
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE293881_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 32 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1246649 and SRA study SRP576091. Searching any of these in the dataset finder brings you back here.

Study design
16 conditions, mostly in duplicate
Female WT MGE, mouse E13 ×2 Female WT Hypothalamus, mouse E13 ×2 Female Homo MGE, mouse E13 ×2 Female Homo Hypothalamus, mouse E13 ×2 Male WT MGE, mouse E13 ×2 Male WT Hypothalamus, mouse E13 ×2 Male Homo MGE, mouse E13 ×2 Male Homo Hypothalamus, mouse E13 ×2 +8 more

Supports a between-group comparison across 32 samples.

16 replicated groups read from 32 sample titles; they account for 32 of them. Check it against the sample list below before relying on it.

Samples in this study
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