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Reprogramming of epidermal keratinocytes by PITX1 transforms the cutaneous cellular landscape and promotes wound healing [CUT&Tag]

GSE279042 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 30 samples Submitted 2026/04/27 Platform GPL24247
Summary
Skin injuries heal slowly, compared to oral epithelial tissues, and often do not regenerate lost adnexa. Using a murine mouse model expressing the oral epithelial transcription factor PITX1 in the skin, we performed CUT&Tag-seq analysis in healthy skin to delinate PITX1 and histone occupancies in the skin.
Published in
Reprogramming of epidermal keratinocytes by PITX1 transforms the cutaneous cellular landscape and promotes wound healing
Overmiller AM, Uchiyama A, Hope ED et al. · JCI insight 2024 · PMID 39480496 · doi:10.1172/jci.insight.182844
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Direct links to NCBI, no account and no request form: the whole study as GSE279042_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 30 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1170234 and SRA study SRP537302. Searching any of these in the dataset finder brings you back here.

Study design
10 conditions, mostly in triplicate
Control Skin IgG ×3 Control Skin Pitx1 ×3 Control Skin H3K4me3 ×3 Control Skin H3K27ac ×3 Control Skin H3K27me3 ×3 PITX1+ Skin IgG ×3 PITX1+ Skin Pitx1 ×3 PITX1+ Skin H3K4me3 ×3 +2 more

Supports a between-group comparison across 30 samples.

10 replicated groups read from 30 sample titles; they account for 30 of them. Check it against the sample list below before relying on it.

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