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RNA-Seq analysis LPCAT3 knockdown effect on primary human endometrial stromal cells(HESC).

GSE274335 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/08/08 Platform GPL24676
Summary
Decidualization of human endometrial stromal cells (HESCs) is a critical process in the establishment of uterine receptivity and successful pregnancy. It involves profound cellular and molecular changes, including alterations in energy metabolism, which are necessary to support the increased metabolic demands of the decidualizing cells. The enzyme lysophosphatidylcholine acyltransferase 3 (LPCAT3), known for its role in lipid remodeling, is hypothesized to influence the metabolic shifts occurring during HESC decidualization. To explore this hypothesis, we employed RNA sequencing (RNA-Seq) to assess the transcriptomic changes in HESCs following LPCAT3 knockdown during the decidualization process.
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Direct links to NCBI, no account and no request form: the whole study as GSE274335_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1145986 and SRA study SRP525088. Searching any of these in the dataset finder brings you back here.

Study design
3 × HESCs, siLPCAT3, vs 3 × HESCs, siNC,

Supports a between-group comparison across 6 samples.

2 replicated groups read from 6 sample titles; they account for 6 of them. Check it against the sample list below before relying on it.

Samples in this study
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