GEO series
Aldehydes alter TGF-β signaling and induce obesity and cancer
GSE273561
Homo sapiens; Mus musculus
Expression profiling by high throughput sequencing
27 samples
Submitted 2024/08/06
Platform GPL24676Platform GPL24247
Summary
Obesity and fatty liver diseases-metabolic dysfunction-associated steatotic liver disease (MASLD and MASH) affect over a third of the global population and are exacerbated in individuals with reduced functional aldehyde dehydrogenase 2 (ALDH2), observed in approximately 560 million people. Current treatment to prevent disease progression to cancer remains inadequate, requiring innovative approaches. We observe that Aldh2-/- and Aldh2-/-Sptbn1+/- (ASKO) mice develop phenotypes of human Metabolic Syndrome (MetS) and MASH with altered lipid metabolism and TGF-β signaling, leading to pro-fibrotic and pro-oncogenic phenotypes, which is restored to normal with siRNA to SPTBN1. Significantly, therapeutic inhibition of SPTBN1 blocks MASH and fibrosis in a human 3D MASH model. This study identifies SPTBN1 as a critical regulator of the functional phenotype of toxic aldehyde-induced MASH and a potential therapeutic target.
Published in
Yang X, Bhowmick K, Rao S et al.
· Cell reports 2024
· PMID 39217614
· doi:10.1016/j.celrep.2024.114676
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE273561_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 27 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1142410 and SRA study SRP523313. Searching any of these in the dataset finder brings you back here.
Study design
27 conditions, each sampled once — no replicated groups
Read from 27 sample titles: 27 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM8432342 Aldh2-/-, snRNAseq
- GSM8432343 Aldh2-/-Sptbn1+/-, snRNAseq
- GSM8432344 WT, snRNAseq
- GSM8432345 Sptbn1+/-, snRNAseq
- GSM8432346 siCtrl, replicate 1, RNAseq
- GSM8432347 siCtrl, replicate 2, RNAseq
- GSM8432348 siCtrl, replicate 3, RNAseq
- GSM8432349 25nM siSptbn1, replicate 1, RNAseq
- GSM8432350 25nM siSptbn1, replicate 2, RNAseq
- GSM8432351 25nM siSptbn1, replicate 3, RNAseq
- GSM8432352 50nM siSptbn1, replicate 1, RNAseq
- GSM8432353 50nM siSptbn1, replicate 2, RNAseq
- GSM8432354 50nM siSptbn1, replicate 3, RNAseq
- GSM8443184 wild type, replicate 1, RNAseq
- GSM8443185 wild type, replicate 2, RNAseq
- GSM8443186 wild type, replicate 3, RNAseq
- GSM8443187 wild type, replicate 4, RNAseq
- GSM8443188 wild type, replicate 5, RNAseq
- GSM8443189 Aldh2-/-, replicate 1, RNAseq
- GSM8443190 Aldh2-/-, replicate 2, RNAseq
- GSM8443191 Aldh2-/-, replicate 3, RNAseq
- GSM8443192 Aldh2-/-, replicate 4, RNAseq
- GSM8443193 Aldh2-/-Sptbn1+/-, replicate 1, RNAseq
- GSM8443194 Aldh2-/-Sptbn1+/-, replicate 2, RNAseq
- GSM8443195 Aldh2-/-Sptbn1+/-, replicate 3, RNAseq
- GSM8443196 Aldh2-/-Sptbn1+/-, replicate 4, RNAseq
- GSM8443197 Aldh2-/-Sptbn1+/-, replicate 5, RNAseq
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