GEO series
Comprehensive transcriptomic analysis of immune-related genes in diabetic foot ulcers: New insights into mechanisms and therapeutic targets
GSE199939
Homo sapiens
Expression profiling by high throughput sequencing
21 samples
Submitted 2024/05/30
Platform GPL24676
Summary
We performed RNA-seq on tissue biopsies derived from patients with DFU and compared it to healthy controls who had similar foot surgery to identify the significant immune related differentially expressed genes between normal and DFU samples. Our results identified that there was a total of 8800 DEGs detected by RNA-seq data analysis, among which 2351 were upregulated and 6449 downregulated genes in DFU. 526 differential IRGs were obtained from intersection of DEGs and IRGs. These results suggest that a deregulated immune cells contribute to pathogenesis of DFUs.The purpose of this study was to identify the key biomarkers of the abnormally expressed genes and immune infiltration in the diabetic wound and to provide diagnostic and therapeutic targets for DFU.
Published in
Jiang N, Xu C, Xu Y et al.
· International immunopharmacology 2024
· PMID 39079197
· doi:10.1016/j.intimp.2024.112638
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE199939_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 21 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA822286 and SRA study SRP367217. Searching any of these in the dataset finder brings you back here.
Study design
21 conditions, each sampled once — no replicated groups
Read from 21 sample titles: 21 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM5994301 Diabetic Foot Skin Donor #1 [DW1]
- GSM5994302 Diabetic Foot Skin Donor #2 [DW2]
- GSM5994303 Diabetic Foot Skin Donor #3 [DW3]
- GSM5994304 Diabetic Foot Skin Donor #4 [DW4]
- GSM5994305 Diabetic Foot Skin Donor #5 [DW5]
- GSM5994306 Diabetic Foot Skin Donor #6 [DW6]
- GSM5994307 Diabetic Foot Skin Donor #7 [DW7]
- GSM5994308 Diabetic Foot Skin Donor #8 [DW8]
- GSM5994309 Diabetic Foot Skin Donor #9 [DW9]
- GSM5994310 Diabetic Foot Skin Donor #10 [DW10]
- GSM5994311 Non-Diabetic Foot Skin Donor #1 [N1]
- GSM5994312 Non-Diabetic Foot Skin Donor #2 [N2]
- GSM5994313 Non-Diabetic Foot Skin Donor #3 [N3]
- GSM5994314 Non-Diabetic Foot Skin Donor #4 [N4]
- GSM5994315 Non-Diabetic Foot Skin Donor #5 [N5]
- GSM5994316 Non-Diabetic Foot Skin Donor #6 [N6]
- GSM5994317 Non-Diabetic Foot Skin Donor #7 [N7]
- GSM5994318 Non-Diabetic Foot Skin Donor #8 [N8]
- GSM5994319 Non-Diabetic Foot Skin Donor #9 [N9]
- GSM5994320 Non-Diabetic Foot Skin Donor #10 [N10]
- GSM5994321 Non-Diabetic Foot Skin Donor #11 [N11]
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