Inhibition of PAK2 in endothelial cells suppresses tumor angiogenesis and promotes immune sensitization through CXCL10

Direct links to NCBI, no account and no request form: the whole study as GSE312096_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 24 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1372162 and SRA study SRP650328. Searching any of these in the dataset finder brings you back here.

Supports a between-group comparison across 12 samples.

4 replicated groups read from 24 sample titles; they account for 12 of them. Check it against the sample list below before relying on it.

• GSM9337681 LLC tumor, CT-PAK2EC, 1
• GSM9337682 LLC tumor, CT-PAK2EC, 2
• GSM9337683 LLC tumor, CT-PAK2EC, 3
• GSM9337684 LLC tumor, KO-PAK2EC, 1
• GSM9337685 LLC tumor, KO-PAK2EC, 2
• GSM9337686 LLC tumor, KO-PAK2EC, 3
• GSM9337687 HUVEC, siCT, 1
• GSM9337688 HUVEC, siCT, 2
• GSM9337689 HUVEC, siCT, 3
• GSM9337690 HUVEC, siPAK2, 1
• GSM9337691 HUVEC, siPAK2, 2
• GSM9337692 HUVEC, siPAK2, 3
• GSM9337693 HUVEC, siCT, 1.1
• GSM9337694 HUVEC, siCT, 2.1
• GSM9337695 HUVEC, siCT, 3.1
• GSM9337696 HUVEC, siPAK2, 1.1
• GSM9337697 HUVEC, siPAK2, 2.1
• GSM9337698 HUVEC, siPAK2, 3.1
• GSM9337699 HUVEC, siCXCL10, 1.1
• GSM9337700 HUVEC, siCXCL10, 2.1
• GSM9337701 HUVEC, siCXCL10, 3.1
• GSM9337702 HUVEC, siPAK2-siCXCL10, 1.1
• GSM9337703 HUVEC, siPAK2-siCXCL10, 2.1
• GSM9337704 HUVEC, siPAK2-siCXCL10, 3.1

• GSE270550 Mutant CEBPA promotes tolerance to inflammatory stress through deficient AP-1 activation [RNA-Seq] 75 samples
• GSE316054 Targeting the ADAR1 p150 isoform triggers tumor growth inhibition and antitumor immunity to overcome immunotherapy resistance 52 samples
• GSE294355 Dual function of DOT1L suppresses tumor intrinsic immunogenicity in Hepatocellular carcinoma [RNA-seq] 36 samples
• GSE303043 UHRF1 drives subtype-independent aggressiveness and immune evasion in small cell lung cancer through GATA2-ST6GALNAC5 and PRC2 interactions 30 samples
• GSE289625 RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity [RNAseq] 28 samples
• GSE267542 Tumor intrinsic METTL5 induces immune resistance in ovarian cancer by suppressing ferroptosis 18 samples
• GSE260456 DOT1L provides transcriptional memory through PRC1.1 antagonism [RNA-seq] 180 samples
• GSE296402 Interleukin-23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity 66 samples

Search all RNA-seq datasets in GEO →