GEO series
Epigenetic Atlas of Bladder Cancer Reveals Master Transcription Factors and Risk-Associated Regulatory Elements in Luminal and Basal-Squamous Molecular Subtypes
GSE302930
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
92 samples
Submitted 2026/02/16
Platform GPL11154
Summary
We performed histone ChIP-seq, the Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq), and RNA sequencing (RNA-seq) on 28 fresh frozen bladder/upper tract tumor samples. We integrated 64 unique data sets to gain a holistic view of gene regulation in bladder cancer expression/molecular subtypes and nominated candidate subtype-specific master transcription factors (TF) driving expression differences. We also integrated bladder GWAS risk SNPs with H3K27ac ChIP-seq and ATAC-seq data and revealed that risk variants were significantly enriched in genetically determined peaks
This dataset
Download
Direct links to NCBI, no account and no request form: the whole study as GSE302930_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 92 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1292852 and SRA study SRP601648. Searching any of these in the dataset finder brings you back here.
Study design
40 conditions, each sampled once — no replicated groups
Read from the first 40 of 92 sample titles: 40 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM9113898 Patient BL1007; H3K27ac ChIP
- GSM9113899 Patient BL1009; H3K27ac ChIP
- GSM9113900 Patient BL1010; H3K27ac ChIP
- GSM9113901 Patient BL1020; H3K27ac ChIP
- GSM9113902 Patient BL1034; H3K27ac ChIP
- GSM9113903 Patient BL1037; H3K27ac ChIP
- GSM9113904 Patient BL1038; H3K27ac ChIP
- GSM9113905 Patient BL1039; H3K27ac ChIP
- GSM9113906 Patient BL1040; H3K27ac ChIP
- GSM9113907 Patient BL1041; H3K27ac ChIP
- GSM9113908 Patient BL1042; H3K27ac ChIP
- GSM9113909 Patient BL1043; H3K27ac ChIP
- GSM9113910 Patient BL1044; H3K27ac ChIP
- GSM9113911 Patient BL1045; H3K27ac ChIP
- GSM9113912 Patient BL1046; H3K27ac ChIP
- GSM9113913 Patient BL1047; H3K27ac ChIP
- GSM9113914 Patient BL1048; H3K27ac ChIP
- GSM9113915 Patient BL1049; H3K27ac ChIP
- GSM9113916 Patient BL1050; H3K27ac ChIP
- GSM9113917 Patient BL1052; H3K27ac ChIP
- GSM9113918 Patient BL1053; H3K27ac ChIP
- GSM9113919 Patient BL1054; H3K27ac ChIP
- GSM9113920 Patient BL1055; H3K27ac ChIP
- GSM9113921 Patient BL1056; H3K27ac ChIP
- GSM9113922 Patient BL1057; H3K27ac ChIP
- GSM9113923 Patient BL1058; H3K27ac ChIP
- GSM9113924 Patient BL1063; H3K27ac ChIP
- GSM9113925 Patient BL1068; H3K27ac ChIP
- GSM9113926 Patient BL1007; H3K4me2 ChIP
- GSM9113927 Patient BL1009; H3K4me2 ChIP
- GSM9113928 Patient BL1010; H3K4me2 ChIP
- GSM9113929 Patient BL1020; H3K4me2 ChIP
- GSM9113930 Patient BL1034; H3K4me2 ChIP
- GSM9113931 Patient BL1037; H3K4me2 ChIP
- GSM9113932 Patient BL1038; H3K4me2 ChIP
- GSM9113933 Patient BL1039; H3K4me2 ChIP
- GSM9113934 Patient BL1040; H3K4me2 ChIP
- GSM9113935 Patient BL1041; H3K4me2 ChIP
- GSM9113936 Patient BL1042; H3K4me2 ChIP
- GSM9113937 Patient BL1043; H3K4me2 ChIP
+ 52 more — browse all 92 samples with per-sample file links →
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