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Fetal reversion from diverse lineages sustains the intestinal stem cell pool and confers stress resilience.

GSE300603 Mus musculus; Homo sapiens Expression profiling by high throughput sequencing 34 samples Submitted 2026/01/09 Platform GPL24676Platform GPL24247Platform GPL34290Platform GPL34284
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Fetal reversion from diverse lineages sustains the intestinal stem cell pool and confers stress resilience
Kirino S, Uefune F, Miyake K et al. · Communications biology 2026 · PMID 41530496 · doi:10.1038/s42003-026-09533-x
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Direct links to NCBI, no account and no request form: the whole study as GSE300603_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 34 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1281525 and SRA study SRP646666. Searching any of these in the dataset finder brings you back here.

Study design
6 conditions, mostly with about 6 replicates each
MG_Control ×6 MG_5FU ×6 COL_Control ×6 COL_5FU ×6 COL_cWRNE ×3 VIL ×3 Mouse intestinal organoid cultured in matrige… ×1 Mouse intestinal organoid cultured in matrige… ×1 +2 more

Supports a between-group comparison across 30 samples.

6 replicated groups read from 34 sample titles; they account for 30 of them. Check it against the sample list below before relying on it.

Samples in this study
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