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E7386 enhances lenvatinib’s antitumor activity in preclinical models and human hepatocellular carcinoma.

GSE299215 Mus musculus; Homo sapiens Expression profiling by high throughput sequencing 44 samples Submitted 2025/08/21 Platform GPL30173Platform GPL30172
Summary
To study the antitumor and antiangiogenic activity of combining E7386 (an oral protein-protein interaction inhibitor targeting CREB-binding protein (CBP)/β-catenin) with lenvatinib and explore a novel mechanism of action of E7386 that boosts antitumor response.
Published in
E7386 Enhances Lenvatinib's Antitumor Activity in Preclinical Models and Human Hepatocellular Carcinoma
Mesropian A, Gris-Oliver A, Balaseviciute U et al. · Clinical cancer research : an official journal of the American Association for Cancer Research 2025 · PMID 40986544 · doi:10.1158/1078-0432.CCR-25-0725
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE299215_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 44 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1273097 and SRA study SRP590410. Searching any of these in the dataset finder brings you back here.

Study design
10 conditions, mostly with about 4 replicates each
Huh7, DMSO-treated, ×4 Huh7, E7386-treated, ×4 SNU398, DMSO-treated, ×4 SNU398, E7386-treated, ×4 Hep3B, DMSO-treated, ×4 Hep3B, E7386-treated, ×4 SNU387, DMSO-treated, ×4 SNU387, E7386-treated, ×4 +4 more

Supports a between-group comparison across 38 samples.

10 replicated groups read from the first 40 of 44 sample titles; they account for 38 of them. Check it against the sample list below before relying on it.

Samples in this study

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