GPR34 loss-of-function rescues TREM2 metabolic dysfunction and promotes responsive microglial states
Direct links to NCBI, no account and no request form: the whole study as GSE293117_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 56 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1242834 and SRA study SRP573366. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 32 samples.
8 replicated groups read from the first 40 of 56 sample titles; they account for 32 of them. Check it against the sample list below before relying on it.
- GSM8874380 WT, PBS, rep 1
- GSM8874381 WT, Myelin, rep 1
- GSM8874382 GPR34KO, PBS, rep 1
- GSM8874383 GPR34KO, Myelin, rep 1
- GSM8874384 TREM2KO, PBS, rep 1
- GSM8874385 TREM2KO, Myelin, rep 1
- GSM8874386 GPR34, TREM2KO, PBS, rep 1
- GSM8874387 GPR34, TREM2KO, Myelin, rep 1
- GSM8874388 WT, PBS, rep 2
- GSM8874389 WT, Myelin, rep 2
- GSM8874390 GPR34KO, PBS, rep 2
- GSM8874391 GPR34KO, Myelin, rep 2
- GSM8874392 TREM2KO, PBS, rep 2
- GSM8874393 TREM2KO, Myelin, rep 2
- GSM8874394 GPR34, TREM2KO, PBS, rep 2
- GSM8874395 GPR34, TREM2KO, Myelin, rep 2
- GSM8874396 WT, PBS, rep 3
- GSM8874397 WT, Myelin, rep 3
- GSM8874398 GPR34KO, PBS, rep 3
- GSM8874399 GPR34KO, Myelin, rep 3
- GSM8874400 TREM2KO, PBS, rep 3
- GSM8874401 TREM2KO, Myelin, rep 3
- GSM8874402 GPR34, TREM2KO, PBS, rep 3
- GSM8874403 GPR34, TREM2KO, Myelin, rep 3
- GSM8874404 WT, PBS, rep 4
- GSM8874405 WT, Myelin, rep 4
- GSM8874406 GPR34KO, PBS, rep 4
- GSM8874407 GPR34KO, Myelin, rep 4
- GSM8874408 TREM2KO, PBS, rep 4
- GSM8874409 TREM2KO, Myelin, rep 4
- GSM8874410 GPR34, TREM2KO, PBS, rep 4
- GSM8874411 GPR34, TREM2KO, Myelin, rep 4
- GSM8874458 Pool 3, GEX
- GSM8874459 Pool 5, GEX
- GSM8874460 Pool 7, GEX
- GSM8874461 Pool 3, CMO
- GSM8874462 Pool 5, CMO
- GSM8874463 Pool 7, CMO
- GSM8874464 Pool 1A, GEX
- GSM8874465 Pool 1B, GEX
+ 16 more — browse all 56 samples with per-sample file links →
- GSE246221 A Mouse Model for Metabolic Dysfunction-associated Steatotic Liver Disease and Hepatocellular Carcinoma [RNA-seq] 148 samples
- GSE270550 Mutant CEBPA promotes tolerance to inflammatory stress through deficient AP-1 activation [RNA-Seq] 75 samples
- GSE296402 Interleukin-23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity 66 samples
- GSE255108 Targeting CDK7 function in the RNA Polymerase II transcription cycle in inflammatory arthritis 64 samples
- GSE294355 Dual function of DOT1L suppresses tumor intrinsic immunogenicity in Hepatocellular carcinoma [RNA-seq] 36 samples
- GSE328222 Acute rapamycin treatment reveals novel mechanisms of dysfunction in a maternal inflammation mouse model 32 samples
- GSE294753 Serum response factor is essential for endometrial function and prevention of inflammatory fibrosis 24 samples
- GSE312096 Inhibition of PAK2 in endothelial cells suppresses tumor angiogenesis and promotes immune sensitization through CXCL10 24 samples
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.