An EZH2—SREBP2 axis promotes cholesterol biosynthesis and represents a noncanonical vulnerability in tumorigenesis
Direct links to NCBI, no account and no request form: the whole study as GSE287355_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 79 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1212202 and SRA study SRP516671. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 28 samples.
14 replicated groups read from the first 40 of 79 sample titles; they account for 28 of them. Check it against the sample list below before relying on it.
- GSM8366913 HepG2_shControl_1
- GSM8366914 HepG2_shControl_2
- GSM8366915 HepG2_shEZH2_1
- GSM8366916 HepG2_shEZH2_2
- GSM8366917 HepG2_shSREBP2 #664_1
- GSM8366918 HepG2_shSREBP2 #664_2
- GSM8366919 HepG2_shSREBP2 #665_1
- GSM8366920 HepG2_shSREBP2 #665_2
- GSM8366921 HepG2_shSREBP2 #667_1
- GSM8366922 HepG2_shSREBP2 #667_2
- GSM8366923 Huh7_shControl_1
- GSM8366924 Huh7_shControl_2
- GSM8366925 Huh7_shEZH2_1
- GSM8366926 Huh7_shEZH2_2
- GSM8366927 HepG2_DMSO_1
- GSM8366928 HepG2_DMSO_2
- GSM8366929 HepG2_MS7126_1
- GSM8366930 HepG2_MS7126_2
- GSM8366931 HepG2_C24_1
- GSM8366932 HepG2_C24_2
- GSM8366933 HepG2_MS7126N1_1
- GSM8366934 HepG2_MS7126N1_2
- GSM8366935 HepG2_MS7126N2_1
- GSM8366936 HepG2_MS7126N2_2
- GSM8366937 Huh7_DMSO_1
- GSM8366938 Huh7_DMSO_2
- GSM8366939 Huh7_MS7126_1
- GSM8366940 Huh7_MS7126_2
- GSM8366942 HepG2, EZH2, CUT&RUN, CST
- GSM8366943 HepG2, EZH2, CUT&RUN, HA
- GSM8366944 HepG2, H3K27me3, CUT&RUN, CST
- GSM8366945 HepG2, H3K27me3, CUT&RUN, abcam
- GSM8366946 HepG2, H3K27ac, CUT&RUN
- GSM8366947 HepG2, H3K4me3, CUT&RUN
- GSM8366948 HepG2, SREBP2, CUT&RUN
- GSM8366950 Huh7, EZH2, CUT&RUN, CST
- GSM8366951 Huh7, EZH2, CUT&RUN, HA
- GSM8366952 Huh7, H3K27me3, CUT&RUN, CST
- GSM8366953 Huh7, H3K27me3, CUT&RUN, abcam
- GSM8366954 Huh7, H3K27ac, CUT&RUN
+ 39 more — browse all 79 samples with per-sample file links →
- GSE264145 Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer 12 samples
- GSE289420 Astrocyte-derived cholesterol drives synaptic gene expression in developing neurons and reciprocal astrocytic transcriptional programs 416 samples
- GSE281472 Targeting CD206+ macrophages disrupts the establishment of a key anti-tumor immune axis 245 samples
- GSE248948 Spatiotemporal control of SMARCA5 by a MAPK-RUNX1 axis distinguishes mutant KRAS-driven pancreatic malignancy from tissue regeneration 170 samples
- GSE134236 Mutant Kras co-opts a progenitor-derived enhancer network to initiate pancreatic tumorigenesis 166 samples
- GSE287736 Sex-specific KDM6A-HNF4A-CREBH network controls lipoprotein cholesterol metabolism and atherosclerosis via epigenetic reprograming of hepatocytes 138 samples
- GSE248942 Spatiotemporal control of SMARCA5 by a MAPK-RUNX1 axis distinguishes mutant KRAS-driven pancreatic malignancy from tissue regeneration (ATAC-Seq) 123 samples
- GSE295336 H2BE113K mutation promotes breast cancer metastasis through modulating chromatin dynamics 77 samples
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.