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Genomic and single-cell landscape of transformed cutaneous T-cell lymphoma

GSE272005 Homo sapiens Expression profiling by high throughput sequencing; Other 32 samples Submitted 2024/07/12 Platform GPL24676
Summary
Cutaneous T-cell lymphoma (CTCL) is a malignancy of skin-homing T cells. A subgroup of patients develops large cell transformation with progression to an aggressive lymphoma and with poor survival. We aimed to study the transformed CTCL (tCTCL) ecosystem using integrative approaches spanning whole-exome sequencing (WES), single-cell RNAseq, and immune profiling in a unique cohort of 56 patients with tCTCL
Published in
Genomic and Single-Cell Landscape Reveals Novel Drivers and Therapeutic Vulnerabilities of Transformed Cutaneous T-cell Lymphoma
Song X, Chang S, Seminario-Vidal L et al. · Cancer discovery 2022 · PMID 35247891 · doi:10.1158/2159-8290.CD-21-1207
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Direct links to NCBI, no account and no request form: the whole study as GSE272005_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 32 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA754592 and SRA study SRP332550. Searching any of these in the dataset finder brings you back here.

Study design
32 conditions, each sampled once — no replicated groups

Read from 32 sample titles: 32 distinct titles with little repetition. Check it against the sample list below before relying on it.

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