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Inhibition of DEK contributes to the tolerance of replication stress and restores HSC function in Fanconi anemia

GSE267491 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 91 samples Submitted 2025/01/03 Platform GPL24676Platform GPL24247
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Inhibition of DEK restores hematopoietic stem cell function in Fanconi anemia
Chen Z, Wu F, Li Y et al. · The Journal of experimental medicine 2025 · PMID 39836085 · doi:10.1084/jem.20241248
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE267491_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 91 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1111561 and SRA study SRP507650. Searching any of these in the dataset finder brings you back here.

Study design
19 conditions, mostly in duplicate
HSC-DMSO ×3 HSC-Gem ×2 HSC-HU ×2 ATAC HSC-DMSO ×2 ATAC HSC-Gem ×2 ATAC HSC-ATAC HU ×2 CUT-Tag HSC-DMSO ×2 CUT-Tag HSC-Gem ×2 +12 more

Supports a between-group comparison across 39 samples.

19 replicated groups read from the first 40 of 91 sample titles; they account for 39 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 51 more — browse all 91 samples with per-sample file links →

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