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Tracking of donor and recipient immune and leukemia phenotypes after allogeneic stem cell transplantation using mitochondrial DNA mutations. [ASAP-Seq 2]

GSE234552 Homo sapiens Other 30 samples Submitted 2024/08/31 Platform GPL24676
Summary
Mitochondrial DNA mutations (mtDNA) enable deconvolution of donor- and recipient-derived single cell profiles. Here, we provide examples for sensitive donor-recipient deconvolution of peripheral blood and bone marrow ASAP-seq profiles in the context of incipient and overt AML relapse following allogeneic hematopoietic stem cell transplantation. Further, using single cell DNA sequencing (Tapestri), we demonstrate co-evolution of mtDNA and somatic nuclear DNA mutations in relapsed CLL post-HSCT.
Published in
Tracking Rare Single Donor and Recipient Immune and Leukemia Cells after Allogeneic Hematopoietic Cell Transplantation Using Mitochondrial DNA Mutations
Penter L, Cieri N, Maurer K et al. · Blood cancer discovery 2024 · PMID 39236287 · doi:10.1158/2643-3230.BCD-23-0138
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Also filed as BioProject PRJNA982030. Searching any of these in the dataset finder brings you back here.

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